Publikation: High yield expression of catalytically active USP18 (UBP43) using a Trigger Factor fusion system
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2012
Autor:innen
Basters, Anja
Ketscher, Lars
Arkona, Christoph
Rademann, Jörg
Knobeloch, Klaus-Peter
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BMC Biotechnology. 2012, 12(1), 56. eISSN 1472-6750. Available under: doi: 10.1186/1472-6750-12-56
Zusammenfassung
Covalent linkage of the ubiquitin-like protein ISG15 interferes with viral infection and USP18 is the major protease which specifically removes ISG15 from target proteins. Thus, boosting ISG15 modification by protease inhibition of USP18 might represent a new strategy to interfere with viral replication. However, so far no heterologous expression system was available to yield sufficient amounts of catalytically active protein for high-throughput based inhibitor screens.
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570 Biowissenschaften, Biologie
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BASTERS, Anja, Lars KETSCHER, Elke DEUERLING, Christoph ARKONA, Jörg RADEMANN, Klaus-Peter KNOBELOCH, Günter FRITZ, 2012. High yield expression of catalytically active USP18 (UBP43) using a Trigger Factor fusion system. In: BMC Biotechnology. 2012, 12(1), 56. eISSN 1472-6750. Available under: doi: 10.1186/1472-6750-12-56BibTex
@article{Basters2012yield-21408,
year={2012},
doi={10.1186/1472-6750-12-56},
title={High yield expression of catalytically active USP18 (UBP43) using a Trigger Factor fusion system},
number={1},
volume={12},
journal={BMC Biotechnology},
author={Basters, Anja and Ketscher, Lars and Deuerling, Elke and Arkona, Christoph and Rademann, Jörg and Knobeloch, Klaus-Peter and Fritz, Günter},
note={Article Number: 56}
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<dcterms:abstract>Covalent linkage of the ubiquitin-like protein ISG15 interferes with viral infection and USP18 is the major protease which specifically removes ISG15 from target proteins. Thus, boosting ISG15 modification by protease inhibition of USP18 might represent a new strategy to interfere with viral replication. However, so far no heterologous expression system was available to yield sufficient amounts of catalytically active protein for high-throughput based inhibitor screens.</dcterms:abstract>
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