Publikation:

The role of APC/C inhibitor Emi2/XErp1 in oscillatory dynamics of early embryonic cell cycles

Vorschaubild

Dateien

Mayer_242287.pdf
Mayer_242287.pdfGröße: 3.12 MBDownloads: 691

Datum

2013

Autor:innen

Vinod, P.K.
Zhou, Xin
Zhang, Tongli
Novak, Bela

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

URI (zitierfähiger Link)
http://nbn-resolving.de/urn:nbn:de:bsz:352-242287
DOI (zitierfähiger Link)
https://doi.org/10.1016/j.bpc.2013.03.002
ArXiv-ID

Internationale Patentnummer

Link zur Lizenz
Urheberrechtlich geschützt

Angaben zur Forschungsförderung

Projekt

Open Access-Veröffentlichung
Open Access Green

Sammlungen

Biologie: Publikationen
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

Biophysical Chemistry. 2013, 177-178, pp. 1-6. ISSN 0301-4622. eISSN 1873-4200. Available under: doi: 10.1016/j.bpc.2013.03.002

Zusammenfassung

The early embryonic Xenopus cell cycles are characterized by alternating oscillations of Cyclin-dependent kinase-1 (Cdk1) and Anaphase Promoting Complex/Cyclosome (APC/C) activities. The early cycles before midblastula transition lack significant inhibitory Cdk1 phosphorylations and are driven by periodic accumulation of Cyclin B before M phase and its degradation by APC/C at the end of M phase. Both experiments and mathematical modelling suggest that while Cdk1:CycB phosphorylation activates APC/C, it inhibits its co-activator Cdc20 (Fizzy). These interactions create an amplified negative-feedback loop which is at the heart of all cell cycle oscillations. Recent experiments find that the APC/C inhibitor, Emi2/XErp1 is essential for large amplitude and short period Cyclin B oscillations during early divisions in the intact Xenopus embryo. This finding is counter-intuitive since larger amplitudes should come with slower cycle times. We explain this paradox by analysing the amplified negative feedback model extended with APC/C inhibition by Emi2. We show that Emi2 interferes with the intrinsic time-delay in APC/C activation and inactivation to increase the amplitude as well as shorten the period of Cyclin B oscillation.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Embryonic cell cycle, oscillation, mathematical modelling, Cyclin-B, Anaphase Promoting Complex, Cyclosome

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Zugehörige Datensätze in KOPS

Zitieren

ISO 690VINOD, P.K., Xin ZHOU, Tongli ZHANG, Thomas U. MAYER, Bela NOVAK, 2013. The role of APC/C inhibitor Emi2/XErp1 in oscillatory dynamics of early embryonic cell cycles. In: Biophysical Chemistry. 2013, 177-178, pp. 1-6. ISSN 0301-4622. eISSN 1873-4200. Available under: doi: 10.1016/j.bpc.2013.03.002
BibTex
@article{Vinod2013-07inhib-24228,
  year={2013},
  doi={10.1016/j.bpc.2013.03.002},
  title={The role of APC/C inhibitor Emi2/XErp1 in oscillatory dynamics of early embryonic cell cycles},
  volume={177-178},
  issn={0301-4622},
  journal={Biophysical Chemistry},
  pages={1--6},
  author={Vinod, P.K. and Zhou, Xin and Zhang, Tongli and Mayer, Thomas U. and Novak, Bela}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/24228">
    <dc:contributor>Zhou, Xin</dc:contributor>
    <dc:creator>Vinod, P.K.</dc:creator>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:creator>Novak, Bela</dc:creator>
    <dcterms:title>The role of APC/C inhibitor Emi2/XErp1 in oscillatory dynamics of early embryonic cell cycles</dcterms:title>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/24228/1/Mayer_242287.pdf"/>
    <dc:contributor>Mayer, Thomas U.</dc:contributor>
    <dc:creator>Mayer, Thomas U.</dc:creator>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-08-23T12:07:35Z</dcterms:available>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:language>eng</dc:language>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/24228/1/Mayer_242287.pdf"/>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dcterms:bibliographicCitation>Biophysical Chemistry ; 177-178 (2013). - S. 1-6</dcterms:bibliographicCitation>
    <dc:contributor>Vinod, P.K.</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-08-23T12:07:35Z</dc:date>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dcterms:abstract xml:lang="eng">The early embryonic Xenopus cell cycles are characterized by alternating oscillations of Cyclin-dependent kinase-1 (Cdk1) and Anaphase Promoting Complex/Cyclosome (APC/C) activities. The early cycles before midblastula transition lack significant inhibitory Cdk1 phosphorylations and are driven by periodic accumulation of Cyclin B before M phase and its degradation by APC/C at the end of M phase. Both experiments and mathematical modelling suggest that while Cdk1:CycB phosphorylation activates APC/C, it inhibits its co-activator Cdc20 (Fizzy). These interactions create an amplified negative-feedback loop which is at the heart of all cell cycle oscillations. Recent experiments find that the APC/C inhibitor, Emi2/XErp1 is essential for large amplitude and short period Cyclin B oscillations during early divisions in the intact Xenopus embryo. This finding is counter-intuitive since larger amplitudes should come with slower cycle times. We explain this paradox by analysing the amplified negative feedback model extended with APC/C inhibition by Emi2. We show that Emi2 interferes with the intrinsic time-delay in APC/C activation and inactivation to increase the amplitude as well as shorten the period of Cyclin B oscillation.</dcterms:abstract>
    <dc:creator>Zhang, Tongli</dc:creator>
    <dc:rights>terms-of-use</dc:rights>
    <dc:creator>Zhou, Xin</dc:creator>
    <dcterms:issued>2013-07</dcterms:issued>
    <dc:contributor>Zhang, Tongli</dc:contributor>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/24228"/>
    <dc:contributor>Novak, Bela</dc:contributor>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet
Diese Publikation teilen