Publikation: Apoptosis in the Dorsal Lateral Geniculate Nucleus after Monocular Deprivation Involves Glutamate Signaling, NO Production, and PARP Activation
Dateien
Datum
Autor:innen
Herausgeber:innen
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
URI (zitierfähiger Link)
DOI (zitierfähiger Link)
Internationale Patentnummer
Link zur Lizenz
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Sammlungen
Core Facility der Universität Konstanz
Titel in einer weiteren Sprache
Publikationstyp
Publikationsstatus
Erschienen in
Zusammenfassung
In mammals, visual experience during early postnatal life is critical for normal development of the visual system. Here we report that monocular deprivation for 2, 7, and 14 consecutive days causes p53 accumulation, cell death, and progressive loss of neurones in the dorsal lateral geniculate nucleus (dLGN) of newborn rats and these are prevented by NMDA and non-NMDA glutamate receptor antagonists, and by L-NAME, an inhibitor of nitric oxide synthesis. Monocular deprivation also increases dLGN levels of citrulline, the coproduct of nitric oxide synthesis, and this, as well as cell death and neuronal loss, is abolished by antagonists of glutamate receptors and by L-NAME. Finally, poly-(ADP-ribose) polymerase (PARP) knock-out mice appear to be protected from monocular deprivation-induced cell death. In conclusion, during early postnatal development of the rat visual system monocular deprivation causes excitotoxic, nitric oxide-mediated, cell death in the dLGN that appears to be apoptotic and also requires activation of PARP.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
Schlagwörter
Konferenz
Rezension
Zitieren
ISO 690
NUCCI, Carlo, Silvia PICCIRILLI, Paola RODINÒ, Robert NISTICÒ, Marina GRANDINETTI, Luciano CERULLI, Marcel LEIST, Pierluigi NICOTERA, Giacinto BAGETTA, 2000. Apoptosis in the Dorsal Lateral Geniculate Nucleus after Monocular Deprivation Involves Glutamate Signaling, NO Production, and PARP Activation. In: Biochemical and Biophysical Research Communications. 2000, 278(2), pp. 360-367. ISSN 0006-291X. eISSN 1090-2104. Available under: doi: 10.1006/bbrc.2000.3811BibTex
@article{Nucci2000-11-19Apopt-40835, year={2000}, doi={10.1006/bbrc.2000.3811}, title={Apoptosis in the Dorsal Lateral Geniculate Nucleus after Monocular Deprivation Involves Glutamate Signaling, NO Production, and PARP Activation}, number={2}, volume={278}, issn={0006-291X}, journal={Biochemical and Biophysical Research Communications}, pages={360--367}, author={Nucci, Carlo and Piccirilli, Silvia and Rodinò, Paola and Nisticò, Robert and Grandinetti, Marina and Cerulli, Luciano and Leist, Marcel and Nicotera, Pierluigi and Bagetta, Giacinto} }
RDF
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/40835"> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-12-05T10:15:25Z</dcterms:available> <dc:contributor>Rodinò, Paola</dc:contributor> <dcterms:abstract xml:lang="eng">In mammals, visual experience during early postnatal life is critical for normal development of the visual system. Here we report that monocular deprivation for 2, 7, and 14 consecutive days causes p53 accumulation, cell death, and progressive loss of neurones in the dorsal lateral geniculate nucleus (dLGN) of newborn rats and these are prevented by NMDA and non-NMDA glutamate receptor antagonists, and by L-NAME, an inhibitor of nitric oxide synthesis. Monocular deprivation also increases dLGN levels of citrulline, the coproduct of nitric oxide synthesis, and this, as well as cell death and neuronal loss, is abolished by antagonists of glutamate receptors and by L-NAME. Finally, poly-(ADP-ribose) polymerase (PARP) knock-out mice appear to be protected from monocular deprivation-induced cell death. In conclusion, during early postnatal development of the rat visual system monocular deprivation causes excitotoxic, nitric oxide-mediated, cell death in the dLGN that appears to be apoptotic and also requires activation of PARP.</dcterms:abstract> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/40835/1/Nucci_2-1pqefdn9j8wrr1.pdf"/> <dc:language>eng</dc:language> <dcterms:issued>2000-11-19</dcterms:issued> <dc:contributor>Grandinetti, Marina</dc:contributor> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:creator>Leist, Marcel</dc:creator> <dcterms:title>Apoptosis in the Dorsal Lateral Geniculate Nucleus after Monocular Deprivation Involves Glutamate Signaling, NO Production, and PARP Activation</dcterms:title> <dc:contributor>Nicotera, Pierluigi</dc:contributor> <dc:creator>Cerulli, Luciano</dc:creator> <dc:contributor>Bagetta, Giacinto</dc:contributor> <dc:contributor>Nucci, Carlo</dc:contributor> <dc:creator>Piccirilli, Silvia</dc:creator> <dc:contributor>Piccirilli, Silvia</dc:contributor> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-12-05T10:15:25Z</dc:date> <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/> <dc:creator>Nucci, Carlo</dc:creator> <dc:contributor>Nisticò, Robert</dc:contributor> <dc:creator>Nisticò, Robert</dc:creator> <foaf:homepage rdf:resource="http://localhost:8080/"/> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/40835/1/Nucci_2-1pqefdn9j8wrr1.pdf"/> <dc:contributor>Cerulli, Luciano</dc:contributor> <dc:creator>Rodinò, Paola</dc:creator> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/> <dc:creator>Grandinetti, Marina</dc:creator> <dc:creator>Bagetta, Giacinto</dc:creator> <dc:contributor>Leist, Marcel</dc:contributor> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/40835"/> <dc:rights>terms-of-use</dc:rights> <dc:creator>Nicotera, Pierluigi</dc:creator> </rdf:Description> </rdf:RDF>