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Exosomal miRNA in chemoresistance, immune evasion, metastasis and progression of cancer

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2019

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Kulkarni, Bhagyashri
Kirave, Prathibha
Gondaliya, Piyush
Jash, Kavya
Tekade, Rakesh K.
Kalia, Kiran

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https://doi.org/10.1016/j.drudis.2019.06.010
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Chemie: Publikationen
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Drug discovery today. 2019, 24(10), pp. 2058-2067. ISSN 1359-6446. eISSN 1878-5832. Available under: doi: 10.1016/j.drudis.2019.06.010

Zusammenfassung

In the treatment of cancer, there are three significant limitations causing high mortality and recurrence rates among cancer patients. First, the escape of tumor cells from the immune system; second, the development of multi-drug resistance (MDR) to chemotherapeutic drugs; and, third, the noxious metastases of cancer cells. Exosomes are vesicular cargos involved in the transportation of miRNA, mRNA and proteins from one cell to another cell. This review details the current understanding of the exosomal transmission of miRNA and crosstalk with the downstream consequences, ultimately leading to the progression and metastasis of cancer. Further, this review also discusses how exosomal miRNA can provide promising novel targets for the treatment and detection of cancer.

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540 Chemie

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ISO 690KULKARNI, Bhagyashri, Prathibha KIRAVE, Piyush GONDALIYA, Kavya JASH, Alok JAIN, Rakesh K. TEKADE, Kiran KALIA, 2019. Exosomal miRNA in chemoresistance, immune evasion, metastasis and progression of cancer. In: Drug discovery today. 2019, 24(10), pp. 2058-2067. ISSN 1359-6446. eISSN 1878-5832. Available under: doi: 10.1016/j.drudis.2019.06.010
BibTex
@article{Kulkarni2019-10Exoso-46240,
  year={2019},
  doi={10.1016/j.drudis.2019.06.010},
  title={Exosomal miRNA in chemoresistance, immune evasion, metastasis and progression of cancer},
  number={10},
  volume={24},
  issn={1359-6446},
  journal={Drug discovery today},
  pages={2058--2067},
  author={Kulkarni, Bhagyashri and Kirave, Prathibha and Gondaliya, Piyush and Jash, Kavya and Jain, Alok and Tekade, Rakesh K. and Kalia, Kiran}
}
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