Publikation:

Extra-adrenal glucocorticoid synthesis in the intestinal epithelium : more than a drop in the ocean?

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2009

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Noti, Mario
Sidler, Daniel

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http://nbn-resolving.de/urn:nbn:de:bsz:352-143498
DOI (zitierfähiger Link)
https://doi.org/10.1007/s00281-009-0159-2
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Seminars in Immunopathology. 2009, 31(2), pp. 237-248. ISSN 1863-2297. eISSN 1863-2300. Available under: doi: 10.1007/s00281-009-0159-2

Zusammenfassung

Glucocorticoids (GC) are lipophilic hormones commonly used as therapeutics in acute and chronic inflammatory disorders such as inflammatory bowel disease due to their attributed anti-inflammatory and immunosuppressive actions. Although the adrenal glands are the major source of endogenous GC, there is increasing evidence for the production of extra-adrenal GC in the brain, thymus, skin, vasculature, and the intestine. However, the physiological relevance of extra-adrenal-produced GC remains still ambiguous. Therefore, this review attracts attention to discuss possible biological benefits of extra-adrenal-synthesized GC, especially focusing on the impact of locally synthesized GC in the regulation of intestinal immune responses.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Intestinal glucocorticoid synthesis, Inflammatory bowel disease (IBD), Intestinal immune homeostasis, Tumor necrosis factor α (TNFα), Liver receptor homologue-1 (LRH-1)

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ISO 690NOTI, Mario, Daniel SIDLER, Thomas BRUNNER, 2009. Extra-adrenal glucocorticoid synthesis in the intestinal epithelium : more than a drop in the ocean?. In: Seminars in Immunopathology. 2009, 31(2), pp. 237-248. ISSN 1863-2297. eISSN 1863-2300. Available under: doi: 10.1007/s00281-009-0159-2
BibTex
@article{Noti2009-07Extra-14349,
  year={2009},
  doi={10.1007/s00281-009-0159-2},
  title={Extra-adrenal glucocorticoid synthesis in the intestinal epithelium : more than a drop in the ocean?},
  number={2},
  volume={31},
  issn={1863-2297},
  journal={Seminars in Immunopathology},
  pages={237--248},
  author={Noti, Mario and Sidler, Daniel and Brunner, Thomas}
}
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