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Osteopontin Stabilizes Metastable States Prior to Nucleation during Apatite Formation

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2016

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Ibsen, Casper Jon Steenberg
Birkedal, Henrik

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https://doi.org/10.1021/acs.chemmater.6b01088
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Chemistry of Materials. 2016, 28(23), pp. 8550-8555. ISSN 0897-4756. eISSN 1520-5002. Available under: doi: 10.1021/acs.chemmater.6b01088

Zusammenfassung

Osteopontin, which is a phosphoprotein with strong ties to in vivo bone mineralization, is shown to change the precipitation pathway of calcium phosphate. We show that the presence of the phosphoprotein, even in minute concentrations, can stabilize an otherwise oversaturated mixture against precipitation. At moderate concentrations, we find that the protein introduces a new intermediate state into the reaction pathway leading to apatite formation. This new intermediate was found to share many characteristics of a coacervate or polymer-induced liquid-like precursor (PILP) phase. Our results show that these types of complex phases should be considered when discussing the mechanisms of bone mineralization on a subcellular level.

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ISO 690IBSEN, Casper Jon Steenberg, Denis GEBAUER, Henrik BIRKEDAL, 2016. Osteopontin Stabilizes Metastable States Prior to Nucleation during Apatite Formation. In: Chemistry of Materials. 2016, 28(23), pp. 8550-8555. ISSN 0897-4756. eISSN 1520-5002. Available under: doi: 10.1021/acs.chemmater.6b01088
BibTex
@article{Ibsen2016-12-13Osteo-37237,
  year={2016},
  doi={10.1021/acs.chemmater.6b01088},
  title={Osteopontin Stabilizes Metastable States Prior to Nucleation during Apatite Formation},
  number={23},
  volume={28},
  issn={0897-4756},
  journal={Chemistry of Materials},
  pages={8550--8555},
  author={Ibsen, Casper Jon Steenberg and Gebauer, Denis and Birkedal, Henrik}
}
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