Publikation:

miR-24 affects hair follicle morphogenesis targeting Tcf-3

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Datum

2013

Autor:innen

Lena, Anna Maria
Bonanno, Elena
Melino, Gerry
Candi, Eleonora

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URI (zitierfähiger Link)
http://nbn-resolving.de/urn:nbn:de:bsz:352-2-1swv6q6pot3652
DOI (zitierfähiger Link)
https://doi.org/10.1038/cddis.2013.426
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Attribution-NonCommercial-NoDerivs 3.0 Unported

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Open Access-Veröffentlichung
Open Access Gold

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Biologie: Publikationen
Core Facility der Universität Konstanz

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Published

Erschienen in

Cell death & disease. Nature Publishing Group. 2013, 4(11), e922. eISSN 2041-4889. Available under: doi: 10.1038/cddis.2013.426

Zusammenfassung

During embryonic development, hair follicles (HFs) develop from an epidermal-mesenchymal cross talk between the ectoderm progenitor layer and the underlying dermis. Epidermal stem cell activation represents a crucial point both for HF morphogenesis and for hair regeneration. miR-24 is an anti-proliferative microRNA (miRNA), which is induced during differentiation of several cellular systems including the epidermis. Here, we show that miR-24 is expressed in the HF and has a role in hair morphogenesis. We generated transgenic mice ectopically expressing miR-24 under the K5 promoter. The K5::miR-24 animals display a marked defect in HF morphogenesis, with thinning of hair coat and altered HF structure. Expression of miR-24 alters the normal process of hair keratinocyte differentiation, leading to altered expression of differentiation markers. MiR-24 directly represses the hair keratinocyte stemness regulator Tcf-3. These results support the notion that microRNAs, and among them miR-24, have an important role in postnatal epidermal homeostasis.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

microRNA, miR-24, hair follicle, skin, Tcf-3, stem cells

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ISO 690AMELIO, Ivano, Anna Maria LENA, Elena BONANNO, Gerry MELINO, Eleonora CANDI, 2013. miR-24 affects hair follicle morphogenesis targeting Tcf-3. In: Cell death & disease. Nature Publishing Group. 2013, 4(11), e922. eISSN 2041-4889. Available under: doi: 10.1038/cddis.2013.426
BibTex
@article{Amelio2013-11-14miR24-57121,
  year={2013},
  doi={10.1038/cddis.2013.426},
  title={miR-24 affects hair follicle morphogenesis targeting Tcf-3},
  number={11},
  volume={4},
  journal={Cell death & disease},
  author={Amelio, Ivano and Lena, Anna Maria and Bonanno, Elena and Melino, Gerry and Candi, Eleonora},
  note={Article Number: e922}
}
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