Publikation:

Structure, enzymatic stability and antitumor activity of sea lamprey GnRH-III and its dimer derivatives

Vorschaubild

Dateien

Zu diesem Dokument gibt es keine Dateien.

Datum

2007

Autor:innen

Mező, Gábor
Czajlik, András
Jakab, Annamaria
Farkas, Viktor
Majer, Zsuzsa
Vass, Elemer
Bodor, Andrea
Kapuvári, Bence
Boldizsar, Mariann
6 mehr anzeigen

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

URI (zitierfähiger Link)
http://nbn-resolving.de/urn:nbn:de:bsz:352-172462
DOI (zitierfähiger Link)
https://doi.org/10.1016/j.peptides.2006.12.014
ArXiv-ID

Internationale Patentnummer

Angaben zur Forschungsförderung

Projekt

Open Access-Veröffentlichung

Sammlungen

Chemie: Publikationen
Zukunftskolleg: Publikationen
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

Peptides. 2007, 28(4), pp. 806-820. ISSN 0196-9781. Available under: doi: 10.1016/j.peptides.2006.12.014

Zusammenfassung

Direct antitumor activity of sea lamprey (Petromyzon marinus) gonadotropin-releasing hormone III (Glp-His-Trp-Ser-His-Asp-Trp-Lys-Pro-Gly-NH2; lGnRH-III) was described on several tumor cells. To improve the selectivity of antitumor effects without increasing the hormone releasing activity and to enhance the enzymatic stability, IGnRH-III dimers were prepared via disulfide bond formation. Our results demonstrate that the IGnRH-III dimer derivatives exhibited higher antiproliferative effect and enzymatic stability in comparison with the native IGnRH-III, while lower LH-releasing potency was determined. In order to find a correlation between the biological and structural features of these compounds, the conformation of lGnRH-III and its dimer derivatives was determined by ECD, VCD, FT-IR and (1)H NMR.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
540 Chemie

Schlagwörter

lGnRH-III dimer, Receptor binding, Antitumor activity, Enzymatic stability, Structure, Gonadotropin-releasing-hormone, Cancer cell-growth, Analogs, Breast, Binding

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Zugehörige Datensätze in KOPS

Zitieren

ISO 690MEZŐ, Gábor, András CZAJLIK, Marilena MANEA, Annamaria JAKAB, Viktor FARKAS, Zsuzsa MAJER, Elemer VASS, Andrea BODOR, Bence KAPUVÁRI, Mariann BOLDIZSAR, Borbála VINCZE, Orsolya CSUKA, Magdolna KOVACS, Michael PRZYBYLSKI, Andras PERCZEL, Ferenc HUDECZ, 2007. Structure, enzymatic stability and antitumor activity of sea lamprey GnRH-III and its dimer derivatives. In: Peptides. 2007, 28(4), pp. 806-820. ISSN 0196-9781. Available under: doi: 10.1016/j.peptides.2006.12.014
BibTex
@article{Mezo2007-04Struc-17246,
  year={2007},
  doi={10.1016/j.peptides.2006.12.014},
  title={Structure, enzymatic stability and antitumor activity of sea lamprey GnRH-III and its dimer derivatives},
  number={4},
  volume={28},
  issn={0196-9781},
  journal={Peptides},
  pages={806--820},
  author={Mező, Gábor and Czajlik, András and Manea, Marilena and Jakab, Annamaria and Farkas, Viktor and Majer, Zsuzsa and Vass, Elemer and Bodor, Andrea and Kapuvári, Bence and Boldizsar, Mariann and Vincze, Borbála and Csuka, Orsolya and Kovacs, Magdolna and Przybylski, Michael and Perczel, Andras and Hudecz, Ferenc}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/17246">
    <dc:contributor>Majer, Zsuzsa</dc:contributor>
    <dc:contributor>Perczel, Andras</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-12-01T07:47:17Z</dc:date>
    <dc:contributor>Przybylski, Michael</dc:contributor>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/52"/>
    <dcterms:abstract xml:lang="eng">Direct antitumor activity of sea lamprey (Petromyzon marinus) gonadotropin-releasing hormone III (Glp-His-Trp-Ser-His-Asp-Trp-Lys-Pro-Gly-NH2; lGnRH-III) was described on several tumor cells. To improve the selectivity of antitumor effects without increasing the hormone releasing activity and to enhance the enzymatic stability, IGnRH-III dimers were prepared via disulfide bond formation. Our results demonstrate that the IGnRH-III dimer derivatives exhibited higher antiproliferative effect and enzymatic stability in comparison with the native IGnRH-III, while lower LH-releasing potency was determined. In order to find a correlation between the biological and structural features of these compounds, the conformation of lGnRH-III and its dimer derivatives was determined by ECD, VCD, FT-IR and (1)H NMR.</dcterms:abstract>
    <dc:creator>Czajlik, András</dc:creator>
    <dcterms:bibliographicCitation>Publ. in: Peptides ; 28 (2007), 4. - S. 806-820</dcterms:bibliographicCitation>
    <dc:contributor>Mező, Gábor</dc:contributor>
    <dc:creator>Hudecz, Ferenc</dc:creator>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-12-01T07:47:17Z</dcterms:available>
    <dc:creator>Farkas, Viktor</dc:creator>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/52"/>
    <dc:rights>terms-of-use</dc:rights>
    <dc:contributor>Kapuvári, Bence</dc:contributor>
    <dc:contributor>Farkas, Viktor</dc:contributor>
    <dc:creator>Mező, Gábor</dc:creator>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dcterms:issued>2007-04</dcterms:issued>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dc:creator>Vincze, Borbála</dc:creator>
    <dc:creator>Manea, Marilena</dc:creator>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/29"/>
    <dc:contributor>Manea, Marilena</dc:contributor>
    <dc:creator>Kapuvári, Bence</dc:creator>
    <dc:contributor>Kovacs, Magdolna</dc:contributor>
    <dc:creator>Csuka, Orsolya</dc:creator>
    <dc:contributor>Vincze, Borbála</dc:contributor>
    <dc:contributor>Vass, Elemer</dc:contributor>
    <dc:creator>Kovacs, Magdolna</dc:creator>
    <dc:creator>Bodor, Andrea</dc:creator>
    <dc:contributor>Hudecz, Ferenc</dc:contributor>
    <dc:creator>Boldizsar, Mariann</dc:creator>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/17246"/>
    <dc:creator>Przybylski, Michael</dc:creator>
    <dc:contributor>Bodor, Andrea</dc:contributor>
    <dcterms:title>Structure, enzymatic stability and antitumor activity of sea lamprey GnRH-III and its dimer derivatives</dcterms:title>
    <dc:contributor>Czajlik, András</dc:contributor>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:contributor>Jakab, Annamaria</dc:contributor>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/29"/>
    <dc:creator>Majer, Zsuzsa</dc:creator>
    <dc:creator>Vass, Elemer</dc:creator>
    <dc:creator>Perczel, Andras</dc:creator>
    <dc:contributor>Csuka, Orsolya</dc:contributor>
    <dc:language>eng</dc:language>
    <dc:creator>Jakab, Annamaria</dc:creator>
    <dc:contributor>Boldizsar, Mariann</dc:contributor>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet
Diese Publikation teilen