Time for CHANGE : system-level interventions for bringing forward the date of effective use of NAMs in regulatory toxicology

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dc.contributor.authorMathisen, Gro H.
dc.contributor.authorBearth, Angela
dc.contributor.authorJones, Lowenna B.
dc.contributor.authorHoffmann, Sebastian
dc.contributor.authorVist, Gunn E.
dc.contributor.authorAmes, Heather M.
dc.contributor.authorHusøy, Trine
dc.contributor.authorSvendsen, Camilla
dc.contributor.authorHartung, Thomas
dc.contributor.authorWhaley, Paul
dc.date.accessioned2024-07-19T06:13:15Z
dc.date.available2024-07-19T06:13:15Z
dc.date.issued2024-08
dc.description.abstractThere has been considerable work over the past 20 years designed to bring about a paradigm shift in regulatory toxicology from chemical risk management decisions based on data from animal studies to a “Next Generation Risk Assessments” (NGRAs) system founded on New Approach Methods (NAMs). Whilst all NAM definitions include in silico, in vitro, ex vivo and in chemico approaches (Schmeisser et al. 2023), some also cover in vivo reduction and refinement approaches (ICCVAM 2018; USEPA 2018). The perceived potential benefits of NAMs that are driving the paradigm shift include better protection of humans and the environment, the reduction of animal testing, and ultimately, a faster and more cost-effective test systems for evaluating chemical safety (Dent et al. 2021; USEPA 2014).
dc.description.versionpublisheddeu
dc.identifier.doi10.1007/s00204-024-03802-6
dc.identifier.urihttps://kops.uni-konstanz.de/handle/123456789/70427
dc.language.isoeng
dc.subject.ddc570
dc.titleTime for CHANGE : system-level interventions for bringing forward the date of effective use of NAMs in regulatory toxicologyeng
dc.typeJOURNAL_ARTICLE
dspace.entity.typePublication
kops.citation.bibtex
@article{Mathisen2024-08CHANG-70427,
  year={2024},
  doi={10.1007/s00204-024-03802-6},
  title={Time for CHANGE : system-level interventions for bringing forward the date of effective use of NAMs in regulatory toxicology},
  number={8},
  volume={98},
  issn={0340-5761},
  journal={Archives of Toxicology},
  pages={2299--2308},
  author={Mathisen, Gro H. and Bearth, Angela and Jones, Lowenna B. and Hoffmann, Sebastian and Vist, Gunn E. and Ames, Heather M. and Husøy, Trine and Svendsen, Camilla and Hartung, Thomas and Whaley, Paul}
}
kops.citation.iso690MATHISEN, Gro H., Angela BEARTH, Lowenna B. JONES, Sebastian HOFFMANN, Gunn E. VIST, Heather M. AMES, Trine HUSØY, Camilla SVENDSEN, Thomas HARTUNG, Paul WHALEY, 2024. Time for CHANGE : system-level interventions for bringing forward the date of effective use of NAMs in regulatory toxicology. In: Archives of Toxicology. Springer. 2024, 98(8), S. 2299-2308. ISSN 0340-5761. eISSN 1432-0738. Verfügbar unter: doi: 10.1007/s00204-024-03802-6deu
kops.citation.iso690MATHISEN, Gro H., Angela BEARTH, Lowenna B. JONES, Sebastian HOFFMANN, Gunn E. VIST, Heather M. AMES, Trine HUSØY, Camilla SVENDSEN, Thomas HARTUNG, Paul WHALEY, 2024. Time for CHANGE : system-level interventions for bringing forward the date of effective use of NAMs in regulatory toxicology. In: Archives of Toxicology. Springer. 2024, 98(8), pp. 2299-2308. ISSN 0340-5761. eISSN 1432-0738. Available under: doi: 10.1007/s00204-024-03802-6eng
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