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Time for CHANGE : system-level interventions for bringing forward the date of effective use of NAMs in regulatory toxicology

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2024

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Mathisen, Gro H.
Bearth, Angela
Jones, Lowenna B.
Vist, Gunn E.
Ames, Heather M.
Husøy, Trine
Svendsen, Camilla
Whaley, Paul
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Archives of Toxicology. Springer. 2024, 98(8), S. 2299-2308. ISSN 0340-5761. eISSN 1432-0738. Verfügbar unter: doi: 10.1007/s00204-024-03802-6

Zusammenfassung

There has been considerable work over the past 20 years designed to bring about a paradigm shift in regulatory toxicology from chemical risk management decisions based on data from animal studies to a “Next Generation Risk Assessments” (NGRAs) system founded on New Approach Methods (NAMs). Whilst all NAM definitions include in silico, in vitro, ex vivo and in chemico approaches (Schmeisser et al. 2023), some also cover in vivo reduction and refinement approaches (ICCVAM 2018; USEPA 2018). The perceived potential benefits of NAMs that are driving the paradigm shift include better protection of humans and the environment, the reduction of animal testing, and ultimately, a faster and more cost-effective test systems for evaluating chemical safety (Dent et al. 2021; USEPA 2014).

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570 Biowissenschaften, Biologie

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ISO 690MATHISEN, Gro H., Angela BEARTH, Lowenna B. JONES, Sebastian HOFFMANN, Gunn E. VIST, Heather M. AMES, Trine HUSØY, Camilla SVENDSEN, Thomas HARTUNG, Paul WHALEY, 2024. Time for CHANGE : system-level interventions for bringing forward the date of effective use of NAMs in regulatory toxicology. In: Archives of Toxicology. Springer. 2024, 98(8), S. 2299-2308. ISSN 0340-5761. eISSN 1432-0738. Verfügbar unter: doi: 10.1007/s00204-024-03802-6
BibTex
@article{Mathisen2024-08CHANG-70427,
  year={2024},
  doi={10.1007/s00204-024-03802-6},
  title={Time for CHANGE : system-level interventions for bringing forward the date of effective use of NAMs in regulatory toxicology},
  number={8},
  volume={98},
  issn={0340-5761},
  journal={Archives of Toxicology},
  pages={2299--2308},
  author={Mathisen, Gro H. and Bearth, Angela and Jones, Lowenna B. and Hoffmann, Sebastian and Vist, Gunn E. and Ames, Heather M. and Husøy, Trine and Svendsen, Camilla and Hartung, Thomas and Whaley, Paul}
}
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