Application of the Inverse-Electron-Demand Diels-Alder Reaction for Metabolic Glycoengineering

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2021
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Frontiers in Chemistry. Frontiers Research Foundation. 2021, 9, 654932. eISSN 2296-2646. Available under: doi: 10.3389/fchem.2021.654932
Zusammenfassung

The inverse electron-demand Diels-Alder (IEDDA or DAinv) reaction is an emerging bioorthogonal ligation reaction that finds application in all areas of chemistry and chemical biology. In this review we highlight its application in metabolic glycoengineering (MGE). MGE is a versatile tool to introduce unnatural sugar derivatives that are modified with a chemical reporter group into cellular glycans. The IEDDA reaction can then be used to modify the chemical reporter group allowing, for instance, the visualization or isolation of glycoconjugates. During the last years, many different sugar derivatives as well as reporter groups have been published. These probes are summarized, and their chemical and biological properties are discussed. Furthermore, we discuss examples of MGE and subsequent IEDDA reaction that highlight its suitability for application within living systems.

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540 Chemie
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inverse-electron-demand Diels-Alder reaction, carbohydrates, metabolic engineering, bioorthogonal chemistry, tetrazines
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ISO 690HAIBER, Lisa Maria, Markus KUFLEITNER, Valentin WITTMANN, 2021. Application of the Inverse-Electron-Demand Diels-Alder Reaction for Metabolic Glycoengineering. In: Frontiers in Chemistry. Frontiers Research Foundation. 2021, 9, 654932. eISSN 2296-2646. Available under: doi: 10.3389/fchem.2021.654932
BibTex
@article{Haiber2021-04-13Appli-53384,
  year={2021},
  doi={10.3389/fchem.2021.654932},
  title={Application of the Inverse-Electron-Demand Diels-Alder Reaction for Metabolic Glycoengineering},
  volume={9},
  journal={Frontiers in Chemistry},
  author={Haiber, Lisa Maria and Kufleitner, Markus and Wittmann, Valentin},
  note={Article Number: 654932}
}
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