Publikation: A cradle for new proteins : trigger factor at the ribosome
Lade...
Dateien
Datum
2005
Autor:innen
Herausgeber:innen
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
URI (zitierfähiger Link)
DOI (zitierfähiger Link)
Internationale Patentnummer
Link zur Lizenz
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Open Access Green
Sammlungen
Core Facility der Universität Konstanz
Titel in einer weiteren Sprache
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
Current Opinion in Structural Biology. 2005, 15(2), pp. 204-212. ISSN 0959-440X. Available under: doi: 10.1016/j.sbi.2005.03.005
Zusammenfassung
Newly synthesized proteins leave the ribosome through a narrow tunnel in the large subunit. During ongoing synthesis, nascent protein chains are particularly sensitive to aggregation and degradation because they emerge from the ribosome in an unfolded state. In bacteria, the first protein to interact with nascent chains and facilitate their folding is the ribosomeassociated chaperone trigger factor. Recently, crystal structures of trigger factor and of its ribosome-binding domain in complex with the large ribosomal subunit revealed that the chaperone adopts an extended dragon-shaped fold with a large hydrophobic cradle, which arches over the exit of the ribosomal tunnel and shields newly synthesized proteins. These structural results, together with recent biochemical data on trigger factor and its interplay with other chaperones and factors that interact with the nascent chain, provide a comprehensive view of the role of trigger factor during cotranslational protein folding.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Konferenz
Rezension
undefined / . - undefined, undefined
Zitieren
ISO 690
MAIER, Timm, Lars FERBITZ, Elke DEUERLING, Nenad BAN, 2005. A cradle for new proteins : trigger factor at the ribosome. In: Current Opinion in Structural Biology. 2005, 15(2), pp. 204-212. ISSN 0959-440X. Available under: doi: 10.1016/j.sbi.2005.03.005BibTex
@article{Maier2005cradl-7052,
year={2005},
doi={10.1016/j.sbi.2005.03.005},
title={A cradle for new proteins : trigger factor at the ribosome},
number={2},
volume={15},
issn={0959-440X},
journal={Current Opinion in Structural Biology},
pages={204--212},
author={Maier, Timm and Ferbitz, Lars and Deuerling, Elke and Ban, Nenad}
}RDF
<rdf:RDF
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:dc="http://purl.org/dc/elements/1.1/"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:bibo="http://purl.org/ontology/bibo/"
xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
xmlns:foaf="http://xmlns.com/foaf/0.1/"
xmlns:void="http://rdfs.org/ns/void#"
xmlns:xsd="http://www.w3.org/2001/XMLSchema#" >
<rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/7052">
<dc:creator>Maier, Timm</dc:creator>
<dc:format>application/pdf</dc:format>
<dcterms:abstract xml:lang="eng">Newly synthesized proteins leave the ribosome through a narrow tunnel in the large subunit. During ongoing synthesis, nascent protein chains are particularly sensitive to aggregation and degradation because they emerge from the ribosome in an unfolded state. In bacteria, the first protein to interact with nascent chains and facilitate their folding is the ribosomeassociated chaperone trigger factor. Recently, crystal structures of trigger factor and of its ribosome-binding domain in complex with the large ribosomal subunit revealed that the chaperone adopts an extended dragon-shaped fold with a large hydrophobic cradle, which arches over the exit of the ribosomal tunnel and shields newly synthesized proteins. These structural results, together with recent biochemical data on trigger factor and its interplay with other chaperones and factors that interact with the nascent chain, provide a comprehensive view of the role of trigger factor during cotranslational protein folding.</dcterms:abstract>
<dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
<dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:31:08Z</dc:date>
<dc:creator>Ferbitz, Lars</dc:creator>
<void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
<dcterms:issued>2005</dcterms:issued>
<dc:creator>Deuerling, Elke</dc:creator>
<dc:language>eng</dc:language>
<dc:contributor>Deuerling, Elke</dc:contributor>
<dcterms:title>A cradle for new proteins : trigger factor at the ribosome</dcterms:title>
<dc:rights>Attribution-NonCommercial-NoDerivs 2.0 Generic</dc:rights>
<dc:contributor>Ban, Nenad</dc:contributor>
<dc:contributor>Maier, Timm</dc:contributor>
<dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/7052/1/A_cradle_for_new_proteins.pdf"/>
<dc:creator>Ban, Nenad</dc:creator>
<dcterms:rights rdf:resource="http://creativecommons.org/licenses/by-nc-nd/2.0/"/>
<dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
<dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/7052/1/A_cradle_for_new_proteins.pdf"/>
<dc:contributor>Ferbitz, Lars</dc:contributor>
<foaf:homepage rdf:resource="http://localhost:8080/"/>
<bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/7052"/>
<dcterms:bibliographicCitation>First publ. in: Current Opinion in Structural Biology 15 (2005), 2, pp. 204 212</dcterms:bibliographicCitation>
<dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:31:08Z</dcterms:available>
</rdf:Description>
</rdf:RDF>Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Nein
