Publikation:

Synthesis of DNA Strands Site-Specifically Damaged by C8-Arylamine Purine Adducts and Effects on Various DNA Polymerases

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Boege_opus-86508.pdf
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Datum

2008

Autor:innen

Böge, Nicolas
Jacobsen, Maike I.
Szombati, Zita
Baerns, Sabrina
Di Pasquale, Francesca
Meier, Chris

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URI (zitierfähiger Link)
http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-86508
DOI (zitierfähiger Link)
https://doi.org/10.1002/chem.200800979
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Urheberrechtlich geschützt

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Open Access-Veröffentlichung
Open Access Green

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Chemie: Publikationen
Core Facility der Universität Konstanz

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Titel in einer weiteren Sprache

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Zeitschriftenartikel
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Published

Erschienen in

Chemistry : a European Journal. 2008, 14(35), pp. 11194-11208. ISSN 0947-6539. eISSN 1521-3765. Available under: doi: 10.1002/chem.200800979

Zusammenfassung

C8-Arylamine-dG and C8-arylamine-dA adducts have been prepared using palladium cross-coupling chemistry. These adducts were subsequently converted into the corresponding 5'-O-DMTr-C8-arylamine-3'-O-phosphoramidites and then used for the automated synthesis of different site-specifically modified oligonucleotides. These "damaged" oligonucleotides have been characterized by ESI-MS, UV thermal stability assays, and circular dichroism, and they have been used in EcoRI assays as well as in primer extension studies using various DNA polymerases.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
540 Chemie

Schlagwörter

aromatic amines, cross-coupling, DNA adducts, DNA damage, palladium

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ISO 690BÖGE, Nicolas, Maike I. JACOBSEN, Zita SZOMBATI, Sabrina BAERNS, Francesca DI PASQUALE, Andreas MARX, Chris MEIER, 2008. Synthesis of DNA Strands Site-Specifically Damaged by C8-Arylamine Purine Adducts and Effects on Various DNA Polymerases. In: Chemistry : a European Journal. 2008, 14(35), pp. 11194-11208. ISSN 0947-6539. eISSN 1521-3765. Available under: doi: 10.1002/chem.200800979
BibTex
@article{Boge2008Synth-1019,
  year={2008},
  doi={10.1002/chem.200800979},
  title={Synthesis of DNA Strands Site-Specifically Damaged by C8-Arylamine Purine Adducts and Effects on Various DNA Polymerases},
  number={35},
  volume={14},
  issn={0947-6539},
  journal={Chemistry : a European Journal},
  pages={11194--11208},
  author={Böge, Nicolas and Jacobsen, Maike I. and Szombati, Zita and Baerns, Sabrina and Di Pasquale, Francesca and Marx, Andreas and Meier, Chris}
}
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