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Ribozyme-based transfer RNA switches for post-transcriptional control of amino acid identity in protein synthesis

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2013

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http://nbn-resolving.de/urn:nbn:de:bsz:352-241704
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https://doi.org/10.1021/ja311107p
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Journal of the American Chemical Society. 2013, 135(22), pp. 8222-8226. ISSN 0002-7863. eISSN 1520-5126. Available under: doi: 10.1021/ja311107p

Zusammenfassung

Protein mutants are studied in a variety of contexts in the life sciences. However, individual mutations need to be generated in order to transcribe and translate the respective protein variants. Here, we introduce a novel strategy for controlling the incorporation of different amino acids in response to an amber stop codon by utilizing switchable designer transfer RNAs in Escherichia coli.

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540 Chemie

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ISO 690SARAGLIADIS, Athanasios, Jörg S. HARTIG, 2013. Ribozyme-based transfer RNA switches for post-transcriptional control of amino acid identity in protein synthesis. In: Journal of the American Chemical Society. 2013, 135(22), pp. 8222-8226. ISSN 0002-7863. eISSN 1520-5126. Available under: doi: 10.1021/ja311107p
BibTex
@article{Saragliadis2013-06-05Riboz-24170,
  year={2013},
  doi={10.1021/ja311107p},
  title={Ribozyme-based transfer RNA switches for post-transcriptional control of amino acid identity in protein synthesis},
  number={22},
  volume={135},
  issn={0002-7863},
  journal={Journal of the American Chemical Society},
  pages={8222--8226},
  author={Saragliadis, Athanasios and Hartig, Jörg S.}
}
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