Respiration pattern variability and related default mode network connectivity are altered in remitted depression

Zamoscik, Vera Eva; Schmidt, Stephanie N. L.; Gerchen, Martin Fungisai; Samsouris, Christos; Timm, Christina; Kuehner, Christine; Kirsch, Peter

Respiration pattern variability and related default mode network connectivity are altered in remitted depression

Dateien

Zamoscik_2-1vkxf6ywyy0a69.pdfGröße: 399.6 KBDownloads: 492

Datum

2018

Autor:innen

Zamoscik, Vera Eva

Schmidt, Stephanie N. L.

Gerchen, Martin Fungisai

Samsouris, Christos

Timm, Christina

Kuehner, Christine

Kirsch, Peter

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Psychological Medicine. 2018, 48(14), pp. 2364-2374. ISSN 0033-2917. eISSN 1469-8978. Available under: doi: 10.1017/S0033291717003890

Zusammenfassung

Background
Studies with healthy participants and patients with respiratory diseases suggest a relation between respiration and mood. The aim of the present analyses was to investigate whether emotionally challenged remitted depressed participants show higher respiration pattern variability (RPV) and whether this is related to mood, clinical outcome and increased default mode network connectivity.

Methods
To challenge participants, sad mood was induced with keywords of personal negative life events in individuals with remitted depression [recurrent major depressive disorder (rMDD), n = 30] and matched healthy controls (HCs, n = 30) during functional magnetic resonance imaging. Respiration was measured by means of a built-in respiration belt. Additionally, questionnaires, a daily life assessment of mood and a 3 years follow-up were applied. For replication, we analysed RPV in an independent sample of 53 rMDD who underwent the same fMRI paradigm.

Results
During sad mood, rMDD compared with HC showed greater RPV, with higher variability in pause duration and respiration frequency and lower expiration to inspiration ratio. Higher RPV was related to lower daily life mood and predicted higher depression scores as well as relapses during a 3-year follow-up period. Furthermore, in rMDD compared with HC higher main respiration frequency exhibited a more positive association with connectivity of the posterior cingulate cortex and the right parahippocampal gyrus.

Conclusions
The results suggest a relation between RPV, mood and depression on the behavioural and neural level. Based on our findings, we propose interventions focusing on respiration to be a promising additional tool in the treatment of depression.

Fachgebiet (DDC)

150 Psychologie

Schlagwörter

depression; parahippocampal gyrus; respiration pattern variability; RPV; vulnerability

Zitieren

ISO 690

ZAMOSCIK, Vera Eva, Stephanie N. L. SCHMIDT, Martin Fungisai GERCHEN, Christos SAMSOURIS, Christina TIMM, Christine KUEHNER, Peter KIRSCH, 2018. Respiration pattern variability and related default mode network connectivity are altered in remitted depression. In: Psychological Medicine. 2018, 48(14), pp. 2364-2374. ISSN 0033-2917. eISSN 1469-8978. Available under: doi: 10.1017/S0033291717003890

BibTex

@article{Zamoscik2018-10Respi-45463,
  year={2018},
  doi={10.1017/S0033291717003890},
  title={Respiration pattern variability and related default mode network connectivity are altered in remitted depression},
  number={14},
  volume={48},
  issn={0033-2917},
  journal={Psychological Medicine},
  pages={2364--2374},
  author={Zamoscik, Vera Eva and Schmidt, Stephanie N. L. and Gerchen, Martin Fungisai and Samsouris, Christos and Timm, Christina and Kuehner, Christine and Kirsch, Peter}
}

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    <dcterms:abstract xml:lang="eng">Background&lt;br /&gt;Studies with healthy participants and patients with respiratory diseases suggest a relation between respiration and mood. The aim of the present analyses was to investigate whether emotionally challenged remitted depressed participants show higher respiration pattern variability (RPV) and whether this is related to mood, clinical outcome and increased default mode network connectivity.&lt;br /&gt;&lt;br /&gt;Methods&lt;br /&gt;To challenge participants, sad mood was induced with keywords of personal negative life events in individuals with remitted depression [recurrent major depressive disorder (rMDD), n = 30] and matched healthy controls (HCs, n = 30) during functional magnetic resonance imaging. Respiration was measured by means of a built-in respiration belt. Additionally, questionnaires, a daily life assessment of mood and a 3 years follow-up were applied. For replication, we analysed RPV in an independent sample of 53 rMDD who underwent the same fMRI paradigm.&lt;br /&gt;&lt;br /&gt;Results&lt;br /&gt;During sad mood, rMDD compared with HC showed greater RPV, with higher variability in pause duration and respiration frequency and lower expiration to inspiration ratio. Higher RPV was related to lower daily life mood and predicted higher depression scores as well as relapses during a 3-year follow-up period. Furthermore, in rMDD compared with HC higher main respiration frequency exhibited a more positive association with connectivity of the posterior cingulate cortex and the right parahippocampal gyrus.&lt;br /&gt;&lt;br /&gt;Conclusions&lt;br /&gt;The results suggest a relation between RPV, mood and depression on the behavioural and neural level. Based on our findings, we propose interventions focusing on respiration to be a promising additional tool in the treatment of depression.</dcterms:abstract>
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