Centrality Analysis Methods for Biological Networks and Their Application to Gene Regulatory Networks

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2008
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Koschützki, Dirk
Schreiber, Falk
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Gene Regulation and Systems Biology. 2008, 2, pp. 193-201. eISSN 1177-6250
Zusammenfassung

The structural analysis of biological networks includes the ranking of the vertices based on the connection structure of a network. To support this analysis we discuss centrality measures which indicate the importance of vertices, and demonstrate their applicability on a gene regulatory network. We show that common centrality measures result in different valuations of the vertices and that novel measures tailored to specific biological investigations are useful for the analysis of biological networks, in particular gene regulatory networks.

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004 Informatik
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network analysis, centralities, gene regulatory network, escherichia coli, network motif
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ISO 690KOSCHÜTZKI, Dirk, Falk SCHREIBER, 2008. Centrality Analysis Methods for Biological Networks and Their Application to Gene Regulatory Networks. In: Gene Regulation and Systems Biology. 2008, 2, pp. 193-201. eISSN 1177-6250
BibTex
@article{Koschutzki2008Centr-40491,
  year={2008},
  title={Centrality Analysis Methods for Biological Networks and Their Application to Gene Regulatory Networks},
  url={http://insights.sagepub.com/centrality-analysis-methods-for-biological-networks-and-their-app-article-a787},
  volume={2},
  journal={Gene Regulation and Systems Biology},
  pages={193--201},
  author={Koschützki, Dirk and Schreiber, Falk}
}
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