Publikation: Structural Characterization of Quadruplex DNA with in-cell EPR approaches
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2013
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Bioorganic & Medicinal Chemistry. 2013, 21(20), pp. 6156-6161. ISSN 0968-0896. eISSN 1464-3391. Available under: doi: 10.1016/j.bmc.2013.04.014
Zusammenfassung
Guanosine-rich DNA sequences have the potential to adopt four-stranded conformations termed quadruplexes. The chromosomes of higher organisms are capped by so-called telomeres that are composed of repeats of the sequence TTAGGG. Up to 200 nucleotides of the G-rich strand form an overhang that is suspected to fold into intramolecular G-quadruplexes. Since induction of quadruplexes at the telomeres results in anti-proliferative effects, the intracellular structure of G-quadruplexes is of high interest as an anti-cancer drug target. Here we give a perspective on the elucidation of DNA sequence folds by electron paramagnetic resonance (EPR) distance measurements. The technique complements X-ray crystallography and NMR spectroscopy, as it can be applied in noncrystalline states, is not intrinsically limited by the size of the bio-macromolecular complex, and is able to analyze flexible structures or coexisting DNA conformation.
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HOLDER, Isabelle T., Malte DRESCHER, Jörg S. HARTIG, 2013. Structural Characterization of Quadruplex DNA with in-cell EPR approaches. In: Bioorganic & Medicinal Chemistry. 2013, 21(20), pp. 6156-6161. ISSN 0968-0896. eISSN 1464-3391. Available under: doi: 10.1016/j.bmc.2013.04.014BibTex
@article{Holder2013-10-15Struc-25694,
year={2013},
doi={10.1016/j.bmc.2013.04.014},
title={Structural Characterization of Quadruplex DNA with in-cell EPR approaches},
number={20},
volume={21},
issn={0968-0896},
journal={Bioorganic & Medicinal Chemistry},
pages={6156--6161},
author={Holder, Isabelle T. and Drescher, Malte and Hartig, Jörg S.}
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<dcterms:abstract xml:lang="eng">Guanosine-rich DNA sequences have the potential to adopt four-stranded conformations termed quadruplexes. The chromosomes of higher organisms are capped by so-called telomeres that are composed of repeats of the sequence TTAGGG. Up to 200 nucleotides of the G-rich strand form an overhang that is suspected to fold into intramolecular G-quadruplexes. Since induction of quadruplexes at the telomeres results in anti-proliferative effects, the intracellular structure of G-quadruplexes is of high interest as an anti-cancer drug target. Here we give a perspective on the elucidation of DNA sequence folds by electron paramagnetic resonance (EPR) distance measurements. The technique complements X-ray crystallography and NMR spectroscopy, as it can be applied in noncrystalline states, is not intrinsically limited by the size of the bio-macromolecular complex, and is able to analyze flexible structures or coexisting DNA conformation.</dcterms:abstract>
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