Publikation: Structure/function relationships of lipoteichoic acids
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2005
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Published
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Journal of Endotoxin Research. 2005, 11(6), pp. 348-356. ISSN 0968-0519. Available under: doi: 10.1177/09680519050110061001
Zusammenfassung
The role of lipoteichoic acids (LTAs) from Gram-positive bacteria as immunostimulatory molecules was controversial for many years, as inadequate preparation methods as well as heterogeneous and endotoxin-contaminated commercial preparations led to conflicting results. An improved purification methodology for LTA now yields potent bioactive and chemically defined material, which is currently being characterized in various models. A synthetic analogue of Staphylococcus aureus LTA has proven the structure/function relationship. The key role of D-alanine esters for the immune response of LTA was confirmed by synthetic derivatives. The glycolipid anchor of LTA plays a central role analogous to the lipid A of LPS. Methodological aspects and criteria for quality assessment of LTA preparations are discussed.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Lipoteichoic acid, purification, structural identification, structure/function relationship
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MORATH, Siegfried, Sonja von AULOCK, Thomas HARTUNG, 2005. Structure/function relationships of lipoteichoic acids. In: Journal of Endotoxin Research. 2005, 11(6), pp. 348-356. ISSN 0968-0519. Available under: doi: 10.1177/09680519050110061001BibTex
@article{Morath2005Struc-8263,
year={2005},
doi={10.1177/09680519050110061001},
title={Structure/function relationships of lipoteichoic acids},
number={6},
volume={11},
issn={0968-0519},
journal={Journal of Endotoxin Research},
pages={348--356},
author={Morath, Siegfried and Aulock, Sonja von and Hartung, Thomas}
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<dcterms:abstract xml:lang="eng">The role of lipoteichoic acids (LTAs) from Gram-positive bacteria as immunostimulatory molecules was controversial for many years, as inadequate preparation methods as well as heterogeneous and endotoxin-contaminated commercial preparations led to conflicting results. An improved purification methodology for LTA now yields potent bioactive and chemically defined material, which is currently being characterized in various models. A synthetic analogue of Staphylococcus aureus LTA has proven the structure/function relationship. The key role of D-alanine esters for the immune response of LTA was confirmed by synthetic derivatives. The glycolipid anchor of LTA plays a central role analogous to the lipid A of LPS. Methodological aspects and criteria for quality assessment of LTA preparations are discussed.</dcterms:abstract>
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