Ca2+ regulation in the absence of the iplA gene product in Dictyostelium discoideum

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2005
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Schaloske, Ralph H.
Lusche, Daniel F.
Bezares-Roder, Karen
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BMC Cell Biology. 2005, 6(1), 13. ISSN 1471-2121. eISSN 1471-2121. Available under: doi: 10.1186/1471-2121-6-13
Zusammenfassung

Stimulation of Dictyostelium discoideum with cAMP evokes an elevation of the cytosolic free Ca2+ concentration ([Ca2+]i). The [Ca2+]i-change is composed of liberation of stored Ca2+ and extracellular Ca2+-entry. The significance of the [Ca2+]i-transient for chemotaxis is under debate. Abolition of chemotactic orientation and migration by Ca2+-buffers in the cytosol indicates that a [Ca2+]i-increase is required for chemotaxis. Yet, the iplA- mutant disrupted in a gene bearing similarity to IP3-receptors of higher eukaryotes aggregates despite the absence of a cAMP-induced [Ca2+]i-transient which favours the view that [Ca2+]i-changes are insignificant for chemotaxis.

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570 Biowissenschaften, Biologie
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ISO 690SCHALOSKE, Ralph H., Daniel F. LUSCHE, Karen BEZARES-RODER, Kathrin HAPPLE, Dieter MALCHOW, Christina SCHLATTERER, 2005. Ca2+ regulation in the absence of the iplA gene product in Dictyostelium discoideum. In: BMC Cell Biology. 2005, 6(1), 13. ISSN 1471-2121. eISSN 1471-2121. Available under: doi: 10.1186/1471-2121-6-13
BibTex
@article{Schaloske2005regul-28165,
  year={2005},
  doi={10.1186/1471-2121-6-13},
  title={Ca<sup>2+</sup> regulation in the absence of the iplA gene product in Dictyostelium discoideum},
  number={1},
  volume={6},
  issn={1471-2121},
  journal={BMC Cell Biology},
  author={Schaloske, Ralph H. and Lusche, Daniel F. and Bezares-Roder, Karen and Happle, Kathrin and Malchow, Dieter and Schlatterer, Christina},
  note={Article Number: 13}
}
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