Publikation: Efficient N-Terminal Glycoconjugation of Proteins by the N-End Rule
Lade...
Dateien
Datum
2008
Autor:innen
Herausgeber:innen
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
URI (zitierfähiger Link)
DOI (zitierfähiger Link)
Internationale Patentnummer
Link zur Lizenz
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Open Access Green
Sammlungen
Core Facility der Universität Konstanz
Titel in einer weiteren Sprache
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
ChemBioChem. 2008, 9(8), pp. 1220-1224. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.200800050
Zusammenfassung
Bulky amino acids in positions 2 and 3 of proteins protect both Met and noncanonical azidohomoalanine, introduced by the auxotrophy-based method, from being excised by the enzymes responsible for N-terminal Met excision. Bioorthogonal transformation enables new specific functionalization of target proteins. We validated this general concept by designing an N-terminal glycoconjugated barstar capable of lectin binding without losing its biological activity.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
540 Chemie
Schlagwörter
barstar, cycloadditions, glycoproteins, N-end rules, N-terminal methionine excision
Konferenz
Rezension
undefined / . - undefined, undefined
Zitieren
ISO 690
MERKEL, Lars, Henning S. G. BECKMANN, Valentin WITTMANN, Nediljko BUDISA, 2008. Efficient N-Terminal Glycoconjugation of Proteins by the N-End Rule. In: ChemBioChem. 2008, 9(8), pp. 1220-1224. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.200800050BibTex
@article{Merkel2008Effic-9876,
year={2008},
doi={10.1002/cbic.200800050},
title={Efficient N-Terminal Glycoconjugation of Proteins by the N-End Rule},
number={8},
volume={9},
issn={1439-4227},
journal={ChemBioChem},
pages={1220--1224},
author={Merkel, Lars and Beckmann, Henning S. G. and Wittmann, Valentin and Budisa, Nediljko}
}RDF
<rdf:RDF
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:dc="http://purl.org/dc/elements/1.1/"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:bibo="http://purl.org/ontology/bibo/"
xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
xmlns:foaf="http://xmlns.com/foaf/0.1/"
xmlns:void="http://rdfs.org/ns/void#"
xmlns:xsd="http://www.w3.org/2001/XMLSchema#" >
<rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/9876">
<dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/9876/1/witt_043.pdf"/>
<dcterms:issued>2008</dcterms:issued>
<foaf:homepage rdf:resource="http://localhost:8080/"/>
<dc:language>eng</dc:language>
<dcterms:bibliographicCitation>First publ. in: ChemBioChem 9 (2008), 8, pp. 1220-1224</dcterms:bibliographicCitation>
<dc:contributor>Budisa, Nediljko</dc:contributor>
<dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/9876/1/witt_043.pdf"/>
<dc:creator>Merkel, Lars</dc:creator>
<dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T18:15:01Z</dc:date>
<dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/29"/>
<dcterms:title>Efficient N-Terminal Glycoconjugation of Proteins by the N-End Rule</dcterms:title>
<bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/9876"/>
<dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
<void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
<dc:contributor>Merkel, Lars</dc:contributor>
<dc:contributor>Wittmann, Valentin</dc:contributor>
<dc:format>application/pdf</dc:format>
<dc:rights>terms-of-use</dc:rights>
<dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T18:15:01Z</dcterms:available>
<dc:creator>Beckmann, Henning S. G.</dc:creator>
<dc:creator>Budisa, Nediljko</dc:creator>
<dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/29"/>
<dc:contributor>Beckmann, Henning S. G.</dc:contributor>
<dc:creator>Wittmann, Valentin</dc:creator>
<dcterms:abstract xml:lang="eng">Bulky amino acids in positions 2 and 3 of proteins protect both Met and noncanonical azidohomoalanine, introduced by the auxotrophy-based method, from being excised by the enzymes responsible for N-terminal Met excision. Bioorthogonal transformation enables new specific functionalization of target proteins. We validated this general concept by designing an N-terminal glycoconjugated barstar capable of lectin binding without losing its biological activity.</dcterms:abstract>
</rdf:Description>
</rdf:RDF>Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
