Memory signals from the thalamus : Early thalamocortical phase synchronization entrains gamma oscillations during long-term memory retrieval

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2012
Autor:innen
Zaehle, Tino
Voges, Jürgen
Esslinger, Christine
Hinrichs, Hermann
Schmitt, Friedhelm C.
Heinze, Hans-Jochen
Richardson-Klavehn, Alan
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Neuropsychologia. Elsevier. 2012, 50(14), pp. 3519-3527. ISSN 0028-3932. eISSN 1873-3514. Available under: doi: 10.1016/j.neuropsychologia.2012.08.023
Zusammenfassung

The thalamus is believed to be a key node in human memory networks, however, very little is known about its real-time functional role. Here we examined the dynamics of thalamocortical communication during long-term episodic memory retrieval in two experiments. In Experiment 1, intrathalamic and surface EEG was recorded in an epileptic patient implanted with depth electrodes for brain stimulation therapy. In a recognition memory test, early (300–500 ms) stimulus-linked oscillatory synchrony between mediodorsal thalamic and frontal surface electrodes at beta frequency (20 Hz) was enhanced for correctly remembered old compared to correctly rejected new items. Directionality measures (Granger causality) indicated that the thalamus was the sender, and the neocortex the receiver, of this beta signal, which also modulated the power of neocortical gamma (55–80 Hz) oscillations (cross-frequency coupling). Experiment 2 validated the cross-frequency coupling effects in a healthy participant sample. Confirming the findings from Experiment 1, significantly increased cross-frequency coupling was found over frontal scalp electrodes during successful recognition. Extending anatomical knowledge on thalamic connectivity with frontal neocortex, these results suggest that the thalamus sends an early memory signal to frontal regions, triggering further memory search processes.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
150 Psychologie
Schlagwörter
Intracranial EEG, Cross-frequency coupling, Beta oscillations, Granger causality, Phase synchrony, Stereotactic neurosurgery
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ISO 690STAUDIGL, Tobias, Tino ZAEHLE, Jürgen VOGES, Simon HANSLMAYR, Christine ESSLINGER, Hermann HINRICHS, Friedhelm C. SCHMITT, Hans-Jochen HEINZE, Alan RICHARDSON-KLAVEHN, 2012. Memory signals from the thalamus : Early thalamocortical phase synchronization entrains gamma oscillations during long-term memory retrieval. In: Neuropsychologia. Elsevier. 2012, 50(14), pp. 3519-3527. ISSN 0028-3932. eISSN 1873-3514. Available under: doi: 10.1016/j.neuropsychologia.2012.08.023
BibTex
@article{Staudigl2012-12Memor-48983,
  year={2012},
  doi={10.1016/j.neuropsychologia.2012.08.023},
  title={Memory signals from the thalamus : Early thalamocortical phase synchronization entrains gamma oscillations during long-term memory retrieval},
  number={14},
  volume={50},
  issn={0028-3932},
  journal={Neuropsychologia},
  pages={3519--3527},
  author={Staudigl, Tobias and Zaehle, Tino and Voges, Jürgen and Hanslmayr, Simon and Esslinger, Christine and Hinrichs, Hermann and Schmitt, Friedhelm C. and Heinze, Hans-Jochen and Richardson-Klavehn, Alan}
}
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