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The DEK Protein : an abundant and ubiquitous constituent of mammalian chromatin

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2004

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Scholten, Ingo
Kappes, Ferdinand
Hu, Hong Gang

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https://doi.org/10.1016/j.gene.2004.08.029
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Gene. 2004, 343(1), pp. 1-9. ISSN 0378-1119. eISSN 1879-0038. Available under: doi: 10.1016/j.gene.2004.08.029

Zusammenfassung

The protein DEK is an abundant and ubiquitous chromatin protein in multicellular organisms (not in yeast). It is expressed in more than a million copies/nucleus of rapidly proliferating mammalian cells. DEK has two DNA binding modules of which one includes a SAP box, a sequence motif that DEK shares with a number of other chromatin proteins. DEK has no apparent affinity to specific DNA sequences, but preferentially binds to superhelical and cruciform DNA, and induces positive supercoils into closed circular DNA. The available evidence strongly suggests that DEK could function as an architectural protein in chromatin comparable to the better known classic architectural chromatin proteins, the high-mobility group or HMG proteins.

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570 Biowissenschaften, Biologie

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ISO 690WALDMANN, Tanja, Ingo SCHOLTEN, Ferdinand KAPPES, Hong Gang HU, Rolf KNIPPERS, 2004. The DEK Protein : an abundant and ubiquitous constituent of mammalian chromatin. In: Gene. 2004, 343(1), pp. 1-9. ISSN 0378-1119. eISSN 1879-0038. Available under: doi: 10.1016/j.gene.2004.08.029
BibTex
@article{Waldmann2004-12-08Prote-38771,
  year={2004},
  doi={10.1016/j.gene.2004.08.029},
  title={The DEK Protein : an abundant and ubiquitous constituent of mammalian chromatin},
  number={1},
  volume={343},
  issn={0378-1119},
  journal={Gene},
  pages={1--9},
  author={Waldmann, Tanja and Scholten, Ingo and Kappes, Ferdinand and Hu, Hong Gang and Knippers, Rolf}
}
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