Publikation: Drosophila Cyclin J is a mitotically stable Cdk1 partner without essential functions
Dateien
Datum
Autor:innen
Herausgeber:innen
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
DOI (zitierfähiger Link)
Internationale Patentnummer
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Sammlungen
Core Facility der Universität Konstanz
Titel in einer weiteren Sprache
Publikationstyp
Publikationsstatus
Erschienen in
Zusammenfassung
Cyclin J is a cyclin family member that appears to have evolved before the metazoan radiation. Its evolutionary conservation argues for an important role but functional characterizations of Cyclin J have remained very limited. In Drosophila, Cyclin J is expressed only in females. Using transgenic Drosophila lines expressing Cyclin J versions with N- or C-terminal GFP extensions, we demonstrate that it is expressed exclusively in the germline. After low level expression in all nuclei within the germarium, it gets highly enriched in the germinal vesicle within the oocyte until stage 12 of oogenesis, followed by disappearance after germinal vesicle breakdown before the first meiotic division. Surprisingly, Cyclin J is not required for female fertility. Chromosome segregation during female meiosis, as well as the rapid early embryonic cell cycles after fertilization, occurs normally in the complete absence of Cyclin J. Cyclin J with EGFP fused at either N- or C-terminus binds to Cdk1 and not to Cdk2. However, in contrast to the other known Cdk1 partners, the A- and B-type cyclins, Cyclin J is not degraded during mitosis.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
Schlagwörter
Konferenz
Rezension
Zitieren
ISO 690
ALTHOFF, Friederike, Ivana VIKTORINOVÁ, Johanna Maria KASTL, Christian F. LEHNER, 2009. Drosophila Cyclin J is a mitotically stable Cdk1 partner without essential functions. In: Developmental Biology. Elsevier. 2009, 333(2), pp. 263-272. ISSN 0012-1606. eISSN 1095-564X. Available under: doi: 10.1016/j.ydbio.2009.06.042BibTex
@article{Althoff2009-09-15Droso-58467,
year={2009},
doi={10.1016/j.ydbio.2009.06.042},
title={Drosophila Cyclin J is a mitotically stable Cdk1 partner without essential functions},
number={2},
volume={333},
issn={0012-1606},
journal={Developmental Biology},
pages={263--272},
author={Althoff, Friederike and Viktorinová, Ivana and Kastl, Johanna Maria and Lehner, Christian F.}
}RDF
<rdf:RDF
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:dc="http://purl.org/dc/elements/1.1/"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:bibo="http://purl.org/ontology/bibo/"
xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
xmlns:foaf="http://xmlns.com/foaf/0.1/"
xmlns:void="http://rdfs.org/ns/void#"
xmlns:xsd="http://www.w3.org/2001/XMLSchema#" >
<rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/58467">
<dc:contributor>Viktorinová, Ivana</dc:contributor>
<dc:contributor>Kastl, Johanna Maria</dc:contributor>
<dc:creator>Kastl, Johanna Maria</dc:creator>
<foaf:homepage rdf:resource="http://localhost:8080/"/>
<bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/58467"/>
<dc:creator>Viktorinová, Ivana</dc:creator>
<dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
<dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-09-01T09:15:35Z</dcterms:available>
<dc:creator>Althoff, Friederike</dc:creator>
<dc:contributor>Althoff, Friederike</dc:contributor>
<void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
<dc:creator>Lehner, Christian F.</dc:creator>
<dcterms:abstract xml:lang="eng">Cyclin J is a cyclin family member that appears to have evolved before the metazoan radiation. Its evolutionary conservation argues for an important role but functional characterizations of Cyclin J have remained very limited. In Drosophila, Cyclin J is expressed only in females. Using transgenic Drosophila lines expressing Cyclin J versions with N- or C-terminal GFP extensions, we demonstrate that it is expressed exclusively in the germline. After low level expression in all nuclei within the germarium, it gets highly enriched in the germinal vesicle within the oocyte until stage 12 of oogenesis, followed by disappearance after germinal vesicle breakdown before the first meiotic division. Surprisingly, Cyclin J is not required for female fertility. Chromosome segregation during female meiosis, as well as the rapid early embryonic cell cycles after fertilization, occurs normally in the complete absence of Cyclin J. Cyclin J with EGFP fused at either N- or C-terminus binds to Cdk1 and not to Cdk2. However, in contrast to the other known Cdk1 partners, the A- and B-type cyclins, Cyclin J is not degraded during mitosis.</dcterms:abstract>
<dcterms:issued>2009-09-15</dcterms:issued>
<dcterms:title>Drosophila Cyclin J is a mitotically stable Cdk1 partner without essential functions</dcterms:title>
<dc:contributor>Lehner, Christian F.</dc:contributor>
<dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-09-01T09:15:35Z</dc:date>
<dc:language>eng</dc:language>
<dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
</rdf:Description>
</rdf:RDF>
