Publikation:

The Cortisol Paradox of Trauma-Related Disorders : Lower Phasic Responses but Higher Tonic Levels of Cortisol Are Associated with Sexual Abuse in Childhood

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Schalinski_0-302826.pdf
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Datum

2015

Autor:innen

Steudte-Schmiedgen, Susann
Kirschbaum, Clemens

Herausgeber:innen

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URI (zitierfähiger Link)
http://nbn-resolving.de/urn:nbn:de:bsz:352-0-302826
DOI (zitierfähiger Link)
https://doi.org/10.1371/journal.pone.0136921
ArXiv-ID

Internationale Patentnummer

Link zur Lizenz

CC BY 4.0

Angaben zur Forschungsförderung

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Open Access-Veröffentlichung
Open Access Gold

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Psychologie: Publikationen
Core Facility der Universität Konstanz

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Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

PloS one. 2015, 10(8), e0136921. eISSN 1932-6203. Available under: doi: 10.1371/journal.pone.0136921

Zusammenfassung

Objectives
Inconsistent findings exist for the activity of the hypothalamic-pituitary-adrenal (HPA) axis in patients with stress related disorders. Recent studies point towards early life stress as a potential modulator.

Methods
We investigated the impact of childhood sexual abuse on phasic (saliva cortisol reactivity) and tonic (hair cortisol) regulation. Furthermore, we assessed predictors on cortisol accumulation in hair. Women (N = 43) with stress-related disorders underwent a standardized assessment of idiographic adverse and traumatic experiences and psychopathology, while measuring salivary cortisol and, heart rate and blood pressure.

Results
Comparing women with and without childhood sexual abuse revealed lower rates of responders and distinct levels of salivary cortisol to the interview in conjunction with a lower heart rate for the abused group. Childhood adversities, traumatic experiences, and depression contributed to higher hair cortisol levels.

Conclusions
Our finding of lower response rate and distinct salivary cortisol pattern in individuals with childhood sexual abuse compared to individuals without early sexual abuse supports the role of environmental programming for the HPA axis. Both, childhood adversities and traumatic stress emerge as crucial factors for long-term cortisol secretion. Lower or suppressed phasic cortisol responses to trauma-related stimuli may therefore be associated with higher tonic values. Thus, early exposure to adversities may result in a biological distinct phenotype in adult patients with stress-related disorders.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
150 Psychologie

Schlagwörter

Hydrocortisone, Child abuse, Post-traumatic stress disorder, Heart rate, Psychological stress, Hair, Blood pressure, Saliva

Konferenz

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ISO 690SCHALINSKI, Inga, Thomas ELBERT, Susann STEUDTE-SCHMIEDGEN, Clemens KIRSCHBAUM, 2015. The Cortisol Paradox of Trauma-Related Disorders : Lower Phasic Responses but Higher Tonic Levels of Cortisol Are Associated with Sexual Abuse in Childhood. In: PloS one. 2015, 10(8), e0136921. eISSN 1932-6203. Available under: doi: 10.1371/journal.pone.0136921
BibTex
@article{Schalinski2015Corti-33265,
  year={2015},
  doi={10.1371/journal.pone.0136921},
  title={The Cortisol Paradox of Trauma-Related Disorders : Lower Phasic Responses but Higher Tonic Levels of Cortisol Are Associated with Sexual Abuse in Childhood},
  number={8},
  volume={10},
  journal={PloS one},
  author={Schalinski, Inga and Elbert, Thomas and Steudte-Schmiedgen, Susann and Kirschbaum, Clemens},
  note={Article Number: e0136921}
}
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