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Low-resolution data analysis for low-density lipoprotein particle

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2001

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Lunin, Vladimir Y.
Lunina, Natalia L.
Ritter, Stephan
Frey, Ingrid
Berg, Aloys
Podjarny, Alberto D.
Urzhumtsev, Alexandre
Baumstark, Manfred W.

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Acta Crystallographica Section D Biological Crystallography. 2001, 57(1), pp. 108-121. ISSN 0907-4449. eISSN 1399-0047. Available under: doi: 10.1107/S0907444900014608

Zusammenfassung

The knowledge of the molecular structure of LDL, a large lipoprotein complex, is of great interest for medical investigations. Currently available LDL crystals do not diffract to high resolution and do not allow the application of standard crystallographic techniques. Additional difficulties arise because of a very dense crystal packing and the presence of several components with quite different mean densities. Several ab initio phasing methods previously reported by the authors have been successfully applied to find a crystallographic image of LDL at a resolution of 27 Å. The most promising results have been obtained using direct phasing with a connectivity analysis of the electron-density maps. The current image makes it possible to discern a single particle covered by a layer of relatively high density that is asymmetrically distributed on the particle surface. It shows a partition of high and low densities inside the particle and, in particular, strips of varying density in the lipid core.

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570 Biowissenschaften, Biologie

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ISO 690LUNIN, Vladimir Y., Natalia L. LUNINA, Stephan RITTER, Ingrid FREY, Aloys BERG, Kay DIEDERICHS, Alberto D. PODJARNY, Alexandre URZHUMTSEV, Manfred W. BAUMSTARK, 2001. Low-resolution data analysis for low-density lipoprotein particle. In: Acta Crystallographica Section D Biological Crystallography. 2001, 57(1), pp. 108-121. ISSN 0907-4449. eISSN 1399-0047. Available under: doi: 10.1107/S0907444900014608
BibTex
@article{Lunin2001Lowre-6718,
  year={2001},
  doi={10.1107/S0907444900014608},
  title={Low-resolution data analysis for low-density lipoprotein particle},
  number={1},
  volume={57},
  issn={0907-4449},
  journal={Acta Crystallographica Section D Biological Crystallography},
  pages={108--121},
  author={Lunin, Vladimir Y. and Lunina, Natalia L. and Ritter, Stephan and Frey, Ingrid and Berg, Aloys and Diederichs, Kay and Podjarny, Alberto D. and Urzhumtsev, Alexandre and Baumstark, Manfred W.}
}
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