Publikation:

Health monitoring in birds using bio-loggers and whole blood transcriptomics

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Jax_2-1wmrg280kro601.pdf
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Datum

2021

Autor:innen

Müller, Inge
Börno, Stefan
et al.

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URI (zitierfähiger Link)
http://nbn-resolving.de/urn:nbn:de:bsz:352-2-1wmrg280kro601
DOI (zitierfähiger Link)
https://doi.org/10.1038/s41598-021-90212-8
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CC BY 4.0

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Open Access-Veröffentlichung
Open Access Gold

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Informatik und Informationswissenschaft: Publikationen
Biologie: Publikationen
Exzellenzcluster "Centre for the Advanced Study of Collective Behaviour": Publikationen
Core Facility der Universität Konstanz

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Titel in einer weiteren Sprache

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Zeitschriftenartikel
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Published

Erschienen in

Scientific reports. Springer Nature. 2021, 11(1), 10815. eISSN 2045-2322. Available under: doi: 10.1038/s41598-021-90212-8

Zusammenfassung

Monitoring and early detection of emerging infectious diseases in wild animals is of crucial global importance, yet reliable ways to measure immune status and responses are lacking for animals in the wild. Here we assess the usefulness of bio-loggers for detecting disease outbreaks in free-living birds and confirm detailed responses using leukocyte composition and large-scale transcriptomics. We simulated natural infections by viral and bacterial pathogens in captive mallards (Anas platyrhynchos), an important natural vector for avian influenza virus. We show that body temperature, heart rate and leukocyte composition change reliably during an acute phase immune response. Using genome-wide gene expression profiling of whole blood across time points we confirm that immunostimulants activate pathogen-specific gene regulatory networks. By reporting immune response related changes in physiological and behavioural traits that can be studied in free-ranging populations, we provide baseline information with importance to the global monitoring of zoonotic diseases.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Gene expression, Gene ontology, Gene regulatory networks, High-throughput screening, Immunology, Infectious diseases, Innate immune cell, Non-model organisms, RNA sequencing

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ISO 690JAX, Elinor, Inge MÜLLER, Stefan BÖRNO, Hanna BORLINGHAUS, Evi FRICKE, Wolfgang FIEDLER, Karsten KLEIN, Falk SCHREIBER, Martin WIKELSKI, Robert KRAUS, 2021. Health monitoring in birds using bio-loggers and whole blood transcriptomics. In: Scientific reports. Springer Nature. 2021, 11(1), 10815. eISSN 2045-2322. Available under: doi: 10.1038/s41598-021-90212-8
BibTex
@article{Jax2021-05-24Healt-53819,
  year={2021},
  doi={10.1038/s41598-021-90212-8},
  title={Health monitoring in birds using bio-loggers and whole blood transcriptomics},
  number={1},
  volume={11},
  journal={Scientific reports},
  author={Jax, Elinor and Müller, Inge and Börno, Stefan and Borlinghaus, Hanna and Fricke, Evi and Fiedler, Wolfgang and Klein, Karsten and Schreiber, Falk and Wikelski, Martin and Kraus, Robert},
  note={Article Number: 10815}
}
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Interner Vermerk

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