Publikation:

Technologies of directed protein evolution in vivo

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katanaev.pdf
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Datum

2010

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Blagodatski, Artem

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http://nbn-resolving.de/urn:nbn:de:bsz:352-135735
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Open Access-Veröffentlichung
Open Access Green

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Biologie: Publikationen
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Zeitschriftenartikel
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Published

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Cellular and Molecular Life Sciences. 2010, 68(7), pp. 1207-1214. ISSN 1420-682X. eISSN 1420-9071

Zusammenfassung

Directed evolution of proteins for improved or modified functionality is an important branch of modern biotechnology. It has traditionally been performed using various in vitro methods, but more recently, methods of in vivo artificial evolution come into play. In this review, we discuss and compare prokaryotic and eukaryotic-based systems of directed protein evolution in vivo, highlighting their benefits and current limitations and focusing on the biotechnological potential of vertebrate immune cells for the generation of protein diversity by means of the immunoglobulin diversification machinery.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Directed evolution, Protein engineering, Mutator strain, Cell culture-based systems, Somatic hypermutation, Gene conversion

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ISO 690BLAGODATSKI, Artem, Vladimir L. KATANAEV, 2010. Technologies of directed protein evolution in vivo. In: Cellular and Molecular Life Sciences. 2010, 68(7), pp. 1207-1214. ISSN 1420-682X. eISSN 1420-9071
BibTex
@article{Blagodatski2010Techn-13573,
  year={2010},
  title={Technologies of directed protein evolution in vivo},
  number={7},
  volume={68},
  issn={1420-682X},
  journal={Cellular and Molecular Life Sciences},
  pages={1207--1214},
  author={Blagodatski, Artem and Katanaev, Vladimir L.}
}
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