Publikation:

Structures of KOD and 9°N DNA Polymerases Complexed with Primer Template Duplex

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Bergen_240102.pdf
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2013

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ChemBioChem. 2013, 14(9), pp. 1058-1062. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.201300175

Zusammenfassung

Structures of KOD and 9°N DNA polymerases, two enzymes that are widely used to replicate DNA with highly modified nucleotides, were solved at high resolution in complex with primer/template duplex. The data elucidate substrate interaction of the two enzymes and pave the way for further optimisation of the enzymes and substrates.

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Fachgebiet (DDC)
540 Chemie

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DNA replication, family B, modified nucleotide, polymerase chain reaction, X-ray structure

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ISO 690BERGEN, Konrad, Karin BETZ, Wolfram WELTE, Kay DIEDERICHS, Andreas MARX, 2013. Structures of KOD and 9°N DNA Polymerases Complexed with Primer Template Duplex. In: ChemBioChem. 2013, 14(9), pp. 1058-1062. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.201300175
BibTex
@article{Bergen2013-06-17Struc-24010,
  year={2013},
  doi={10.1002/cbic.201300175},
  title={Structures of KOD and 9°N DNA Polymerases Complexed with Primer Template Duplex},
  number={9},
  volume={14},
  issn={1439-4227},
  journal={ChemBioChem},
  pages={1058--1062},
  author={Bergen, Konrad and Betz, Karin and Welte, Wolfram and Diederichs, Kay and Marx, Andreas}
}
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