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ZNF750 represses breast cancer invasion via epigenetic control of prometastatic genes

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2020

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Cassandri, Matteo
Lena, Anna Maria
Montanaro, Manuela
Mauriello, Alessandro
Anemona, Lucia
Candi, Eleonora
Agostini, Massimiliano
Melino, Gerry

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https://doi.org/10.1038/s41388-020-1277-5
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Oncogene. Springer Nature. 2020, 39(22), pp. 4331-4343. ISSN 0950-9232. eISSN 1476-5594. Available under: doi: 10.1038/s41388-020-1277-5

Zusammenfassung

Breast cancer is the second leading cause of cancer-related deaths among women, largely due to the progression of a significant fraction of primary tumours to the metastatic stage. Here, we show that zinc-finger protein 750 (ZNF750) opposes the migration and invasion of breast cancer cells by repressing a prometastatic transcriptional programme, which includes genes involved in focal adhesion and extracellular matrix interactions, such as LAMB3 and CTNNAL1. Mechanistically, ZNF750 recruits the epigenetic modifiers KDM1A and HDAC1 to the promoter regions of LAMB3 and CTNNAL1, influencing histone marks and transactivating these genomic sites. Gene expression analysis in cancer patient datasets indicated that ZNF750 and its targets were negative prognostic factors in breast cancer. Together, our findings shed light on the molecular mechanism by which ZNF750 regulates cell migration and invasion, suggesting a role in breast cancer metastasis.

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570 Biowissenschaften, Biologie

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ISO 690CASSANDRI, Matteo, Alessio BUTERA, Ivano AMELIO, Anna Maria LENA, Manuela MONTANARO, Alessandro MAURIELLO, Lucia ANEMONA, Eleonora CANDI, Massimiliano AGOSTINI, Gerry MELINO, 2020. ZNF750 represses breast cancer invasion via epigenetic control of prometastatic genes. In: Oncogene. Springer Nature. 2020, 39(22), pp. 4331-4343. ISSN 0950-9232. eISSN 1476-5594. Available under: doi: 10.1038/s41388-020-1277-5
BibTex
@article{Cassandri2020ZNF75-57062,
  year={2020},
  doi={10.1038/s41388-020-1277-5},
  title={ZNF750 represses breast cancer invasion via epigenetic control of prometastatic genes},
  number={22},
  volume={39},
  issn={0950-9232},
  journal={Oncogene},
  pages={4331--4343},
  author={Cassandri, Matteo and Butera, Alessio and Amelio, Ivano and Lena, Anna Maria and Montanaro, Manuela and Mauriello, Alessandro and Anemona, Lucia and Candi, Eleonora and Agostini, Massimiliano and Melino, Gerry}
}
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