Cyanopeptolin 954, a Chlorine-Containing Chymotrypsin Inhibitor of Microcystis aeruginosa NIVA Cya 43

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dc.contributor.authorElert, Eric vondeu
dc.contributor.authorOberer, Lukasdeu
dc.contributor.authorMerkel, Petra
dc.contributor.authorHuhn, Thomas
dc.contributor.authorBlom, Judith F.deu
dc.date.accessioned2011-03-24T18:12:57Zdeu
dc.date.issued2005deu
dc.description.abstractA new depsipeptide, cyanopeptolin 954 (1), was isolated from the freshwater cyanobacterium Microcystis aeruginosa NIVA Cya 43. The structure of the compound was elucidated by chemical and spectroscopic analyses, including 2D NMR and GC-MS of the hydrolysate. The major structural differences compared to previously characterized heptadepsipeptides of Microcystis are the replacement of the basic amino acid in position 4 by l-leucine, the presence of l-phenylalanine in position 6, and the uncommon residue 3 -chloro-N-Me-l-tyrosine in position 7. Cyanopeptolin 954 inhibited chymotrypsin with an IC50 value of 45 nM. Nostopeptin BN920, formerly isolated from the cyanobacterium Nostoc,1 was isolated from the same strain of Microcystis, and a cis amide bond between Phe (6) and N-Me-Tyr (7) was shown. Nostopeptin BN920 inhibited chymotrypsin with an IC50 value of 31 nM.eng
dc.description.versionpublished
dc.format.mimetypeapplication/pdfdeu
dc.identifier.citationFirst publ. in: Journal of Natural Products ; 68 (2005), 9. - S. 1324-1327deu
dc.identifier.doi10.1021/np050079r
dc.identifier.pmid16180807
dc.identifier.ppn306705001deu
dc.identifier.urihttp://kops.uni-konstanz.de/handle/123456789/9588
dc.language.isoengdeu
dc.legacy.dateIssued2009deu
dc.rightsAttribution-NonCommercial-NoDerivs 2.0 Generic
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.0/
dc.subject.ddc570deu
dc.subject.gndBiochemische Analysedeu
dc.titleCyanopeptolin 954, a Chlorine-Containing Chymotrypsin Inhibitor of Microcystis aeruginosa NIVA Cya 43eng
dc.typeJOURNAL_ARTICLEdeu
dspace.entity.typePublication
kops.citation.bibtex
@article{Elert2005Cyano-9588,
  year={2005},
  doi={10.1021/np050079r},
  title={Cyanopeptolin 954, a Chlorine-Containing Chymotrypsin Inhibitor of Microcystis aeruginosa NIVA Cya 43},
  number={9},
  volume={68},
  issn={0163-3864},
  journal={Journal of Natural Products},
  pages={1324--1327},
  author={Elert, Eric von and Oberer, Lukas and Merkel, Petra and Huhn, Thomas and Blom, Judith F.}
}
kops.citation.iso690ELERT, Eric von, Lukas OBERER, Petra MERKEL, Thomas HUHN, Judith F. BLOM, 2005. Cyanopeptolin 954, a Chlorine-Containing Chymotrypsin Inhibitor of Microcystis aeruginosa NIVA Cya 43. In: Journal of Natural Products. 2005, 68(9), pp. 1324-1327. ISSN 0163-3864. eISSN 1520-6025. Available under: doi: 10.1021/np050079rdeu
kops.citation.iso690ELERT, Eric von, Lukas OBERER, Petra MERKEL, Thomas HUHN, Judith F. BLOM, 2005. Cyanopeptolin 954, a Chlorine-Containing Chymotrypsin Inhibitor of Microcystis aeruginosa NIVA Cya 43. In: Journal of Natural Products. 2005, 68(9), pp. 1324-1327. ISSN 0163-3864. eISSN 1520-6025. Available under: doi: 10.1021/np050079reng
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