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Insights into colloidal nanoparticle-protein corona interactions for nanomedicine applications

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2021

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Martínez-Negro, María
Aicart, Emilio
Landfester, Katharina
Guerrero-Martínez, Andrés
Junquera, Elena

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Advances in Colloid and Interface Science. Elsevier. 2021, 289, 102366. ISSN 0001-8686. eISSN 1873-3727. Available under: doi: 10.1016/j.cis.2021.102366

Zusammenfassung

Colloidal nanoparticles (NPs) have attracted significant attention due to their unique physicochemical properties suitable for diagnosing and treating different human diseases. Nevertheless, the successful implementation of NPs in medicine demands a proper understanding of their interactions with the different proteins found in biological fluids. Once introduced into the body, NPs are covered by a protein corona (PC) that determines the biological behavior of the NPs. The formation of the PC can eventually favor the rapid clearance of the NPs from the body before fulfilling the desired objective or lead to increased cytotoxicity. The PC nature varies as a function of the different repulsive and attractive forces that govern the NP-protein interaction and their colloidal stability. This review focuses on the phenomenon of PC formation on NPs from a physicochemical perspective, aiming to provide a general overview of this critical process. Main issues related to NP toxicity and clearance from the body as a result of protein adsorption are covered, including the most promising strategies to control PC formation and, thereby, ensure the successful application of NPs in nanomedicine.

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540 Chemie

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Colloidal; Nanomedicine; Nanoparticles; Protein corona; Strategies

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ISO 690MARTÍNEZ-NEGRO, María, Guillermo GONZALEZ-RUBIO, Emilio AICART, Katharina LANDFESTER, Andrés GUERRERO-MARTÍNEZ, Elena JUNQUERA, 2021. Insights into colloidal nanoparticle-protein corona interactions for nanomedicine applications. In: Advances in Colloid and Interface Science. Elsevier. 2021, 289, 102366. ISSN 0001-8686. eISSN 1873-3727. Available under: doi: 10.1016/j.cis.2021.102366
BibTex
@article{MartinezNegro2021-03Insig-53448,
  year={2021},
  doi={10.1016/j.cis.2021.102366},
  title={Insights into colloidal nanoparticle-protein corona interactions for nanomedicine applications},
  volume={289},
  issn={0001-8686},
  journal={Advances in Colloid and Interface Science},
  author={Martínez-Negro, María and Gonzalez-Rubio, Guillermo and Aicart, Emilio and Landfester, Katharina and Guerrero-Martínez, Andrés and Junquera, Elena},
  note={Article Number: 102366}
}
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