Publikation:

p53-Mediated Tumor Suppression : DNA-Damage Response and Alternative Mechanisms

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Pitolli_2-1uuvjsolnkug76.pdf
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Datum

2019

Autor:innen

Pitolli, Consuelo
Wang, Ying
Candi, Eleonora
Shi, Yufang
Melino, Gerry

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URI (zitierfähiger Link)
http://nbn-resolving.de/urn:nbn:de:bsz:352-2-1uuvjsolnkug76
DOI (zitierfähiger Link)
https://doi.org/10.3390/cancers11121983
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Internationale Patentnummer

Link zur Lizenz

CC BY 4.0

Angaben zur Forschungsförderung

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Open Access-Veröffentlichung
Open Access Gold

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Psychologie: Publikationen
Core Facility der Universität Konstanz

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Titel in einer weiteren Sprache

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Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

Cancers. MDPI. 2019, 11(12), 1983. ISSN 2072-6694. eISSN 2072-6694. Available under: doi: 10.3390/cancers11121983

Zusammenfassung

The tumor suppressor p53 regulates different cellular pathways involved in cell survival, DNA repair, apoptosis, and senescence. However, according to an increasing number of studies, the p53-mediated canonical DNA damage response is dispensable for tumor suppression. p53 is involved in mechanisms regulating many other cellular processes, including metabolism, autophagy, and cell migration and invasion, and these pathways might crucially contribute to its tumor suppressor function. In this review we summarize the canonical and non-canonical functions of p53 in an attempt to provide an overview of the potentially crucial aspects related to its tumor suppressor activity.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

cell death; cancer; epigenetics; metabolism

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ISO 690PITOLLI, Consuelo, Ying WANG, Eleonora CANDI, Yufang SHI, Gerry MELINO, Ivano AMELIO, 2019. p53-Mediated Tumor Suppression : DNA-Damage Response and Alternative Mechanisms. In: Cancers. MDPI. 2019, 11(12), 1983. ISSN 2072-6694. eISSN 2072-6694. Available under: doi: 10.3390/cancers11121983
BibTex
@article{Pitolli2019p53Me-57164,
  year={2019},
  doi={10.3390/cancers11121983},
  title={p53-Mediated Tumor Suppression : DNA-Damage Response and Alternative Mechanisms},
  number={12},
  volume={11},
  issn={2072-6694},
  journal={Cancers},
  author={Pitolli, Consuelo and Wang, Ying and Candi, Eleonora and Shi, Yufang and Melino, Gerry and Amelio, Ivano},
  note={Article Number: 1983}
}
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Interner Vermerk

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