Publikation:

Steric Constraints Dependent on Nucleobase Pair Orientation Vary in Different DNA Polymerase Active Sites

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Streckenbach_86768.pdf
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2009

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Published

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ChemBioChem. 2009, 10(10), pp. 1630-1633. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.200900123

Zusammenfassung

Finding the right fit: Herein, we report on the development of novel steric probes and present initial insights into their interplay with DNA polymerases. Our findings provide experimental evidence for varied enzyme-substrate interactions that might account for the varied selectivity previously observed.

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Fachgebiet (DDC)
540 Chemie

Schlagwörter

base pairing, DNA polymerase, DNA replication, steric effects, steric hindranc

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ISO 690STRECKENBACH, Frank, Gopinath RANGAM, Heiko M. MÖLLER, Andreas MARX, 2009. Steric Constraints Dependent on Nucleobase Pair Orientation Vary in Different DNA Polymerase Active Sites. In: ChemBioChem. 2009, 10(10), pp. 1630-1633. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.200900123
BibTex
@article{Streckenbach2009Steri-1020,
  year={2009},
  doi={10.1002/cbic.200900123},
  title={Steric Constraints Dependent on Nucleobase Pair Orientation Vary in Different DNA Polymerase Active Sites},
  number={10},
  volume={10},
  issn={1439-4227},
  journal={ChemBioChem},
  pages={1630--1633},
  author={Streckenbach, Frank and Rangam, Gopinath and Möller, Heiko M. and Marx, Andreas}
}
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