Publikation: Steric Constraints Dependent on Nucleobase Pair Orientation Vary in Different DNA Polymerase Active Sites
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2009
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ChemBioChem. 2009, 10(10), pp. 1630-1633. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.200900123
Zusammenfassung
Finding the right fit: Herein, we report on the development of novel steric probes and present initial insights into their interplay with DNA polymerases. Our findings provide experimental evidence for varied enzyme-substrate interactions that might account for the varied selectivity previously observed.
Zusammenfassung in einer weiteren Sprache
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540 Chemie
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base pairing, DNA polymerase, DNA replication, steric effects, steric hindranc
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STRECKENBACH, Frank, Gopinath RANGAM, Heiko M. MÖLLER, Andreas MARX, 2009. Steric Constraints Dependent on Nucleobase Pair Orientation Vary in Different DNA Polymerase Active Sites. In: ChemBioChem. 2009, 10(10), pp. 1630-1633. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.200900123BibTex
@article{Streckenbach2009Steri-1020, year={2009}, doi={10.1002/cbic.200900123}, title={Steric Constraints Dependent on Nucleobase Pair Orientation Vary in Different DNA Polymerase Active Sites}, number={10}, volume={10}, issn={1439-4227}, journal={ChemBioChem}, pages={1630--1633}, author={Streckenbach, Frank and Rangam, Gopinath and Möller, Heiko M. and Marx, Andreas} }
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