Publikation:

The duck genome and transcriptome provide insight into an avian influenza virus reservoir species

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Huang_2-1uh4rvqhksou68.pdf
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Datum

2013

Autor:innen

Huang, Yinhua
Li, Yingrui
Burt, David W.
Chen, Hualan
Zhang, Yong
Qian, Wubin
Kim, Heebal
Wang, Jun
Li, Ning
et al.

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http://nbn-resolving.de/urn:nbn:de:bsz:352-2-1uh4rvqhksou68
DOI (zitierfähiger Link)
https://doi.org/10.1038/ng.2657
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Attribution-NonCommercial-ShareAlike 3.0 Unported

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Open Access-Veröffentlichung
Open Access Hybrid

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Biologie: Publikationen
Core Facility der Universität Konstanz

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Published

Erschienen in

Nature genetics. Nature Publishing Group. 2013, 45(7), pp. 776-783. ISSN 1061-4036. eISSN 1546-1718. Available under: doi: 10.1038/ng.2657

Zusammenfassung

The duck (Anas platyrhynchos) is one of the principal natural hosts of influenza A viruses. We present the duck genome sequence and perform deep transcriptome analyses to investigate immune-related genes. Our data indicate that the duck possesses a contractive immune gene repertoire, as in chicken and zebra finch, and this repertoire has been shaped through lineage-specific duplications. We identify genes that are responsive to influenza A viruses using the lung transcriptomes of control ducks and ones that were infected with either a highly pathogenic (A/duck/Hubei/49/05) or a weakly pathogenic (A/goose/Hubei/65/05) H5N1 virus. Further, we show how the duck's defense mechanisms against influenza infection have been optimized through the diversification of its β-defensin and butyrophilin-like repertoires. These analyses, in combination with the genomic and transcriptomic data, provide a resource for characterizing the interaction between host and influenza viruses.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

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ISO 690HUANG, Yinhua, Yingrui LI, David W. BURT, Hualan CHEN, Yong ZHANG, Wubin QIAN, Heebal KIM, Robert KRAUS, Jun WANG, Ning LI, 2013. The duck genome and transcriptome provide insight into an avian influenza virus reservoir species. In: Nature genetics. Nature Publishing Group. 2013, 45(7), pp. 776-783. ISSN 1061-4036. eISSN 1546-1718. Available under: doi: 10.1038/ng.2657
BibTex
@article{Huang2013-07genom-51095,
  year={2013},
  doi={10.1038/ng.2657},
  title={The duck genome and transcriptome provide insight into an avian influenza virus reservoir species},
  number={7},
  volume={45},
  issn={1061-4036},
  journal={Nature genetics},
  pages={776--783},
  author={Huang, Yinhua and Li, Yingrui and Burt, David W. and Chen, Hualan and Zhang, Yong and Qian, Wubin and Kim, Heebal and Kraus, Robert and Wang, Jun and Li, Ning}
}
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Interner Vermerk

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