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Using wearables to screen motor performance deterioration because of cancer and chemotherapy-induced peripheral neuropathy (CIPN) in adults : Toward an early diagnosis of CIPN

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2019

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Zahiri, Mohsen
Chen, Kevin M.
Zhou, He
Nguyen, Hung
Workeneh, Biruh T.
Yellapragada, Sarvari V.
Sada, Yvonne H.
Najafi, Bijan

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http://nbn-resolving.de/urn:nbn:de:bsz:352-2-1u7ygfz4q0lqu9
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https://doi.org/10.1016/j.jgo.2019.01.010
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CC BY-NC-ND 4.0

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Journal of geriatric oncology. 2019, 10(6), pp. 960-967. ISSN 1879-4068. eISSN 1879-4076. Available under: doi: 10.1016/j.jgo.2019.01.010

Zusammenfassung

Objective:
An essential component for optimizing quality of life in adults with cancer is determining the degree to which therapy may negatively impact motor-performance, so that patients can maintain their quality of life and independence. This study examined whether instrumented gait and balance could determine the magnitude of deterioration in motor-performance from chemotherapy-induced peripheral neuropathy (CIPN).

Methods:
We recruited 84 adults with cancer (age = 71.1 ± 9.7 years old, BMI = 26.8 ± 6.2 kg/m2, gender = 56%female) and 57 age-matched non-cancer patients (age = 69.5 ± 9.8 years old, BMI = 27.1 ± 6.0 kg/m2, gender = 79%female). Based on clinical screening, the group with cancer was classified into two groups: participants with CIPN (CIPN+) and without CIPN (CIPN-). Gait and balance were quantified using validated wearables. The Vibration Perception Threshold (VPT) test was used to stratify the CIPN+ group into mild (Mild-CIPN) and severe (Severe-CIPN) subgroups.

Results:
All gait and balance parameters were deteriorated in the group with cancer compared to non-cancer group with the largest effects observed for stride-time (11%, Cohen's effect size d = 1.00, p < 0.001) and eyes-closed ankle sway (94%, d = 0.49, p = 0.001). The same trend was observed when the Severe-CIPN subgroup was compared to the Mild-CIPN. VPT correlates significantly with motor deterioration, with the largest correlation found in stride-time (Rho = 0.37, p = 0.007). Severe-CIPN subjects were significantly older and overall had more deterioration in the majority of motor-performance parameters after adjusting for age (p < 0.050).

Conclusion:
These results confirmed the negative impact of CIPN on motor-performance with the largest effects on ankle stability and stride-time. VPT is a predictor of motor deterioration and may be used to determine the severity of CIPN symptom.

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ISO 690ZAHIRI, Mohsen, Kevin M. CHEN, He ZHOU, Hung NGUYEN, Biruh T. WORKENEH, Sarvari V. YELLAPRAGADA, Yvonne H. SADA, Michael SCHWENK, Bijan NAJAFI, 2019. Using wearables to screen motor performance deterioration because of cancer and chemotherapy-induced peripheral neuropathy (CIPN) in adults : Toward an early diagnosis of CIPN. In: Journal of geriatric oncology. 2019, 10(6), pp. 960-967. ISSN 1879-4068. eISSN 1879-4076. Available under: doi: 10.1016/j.jgo.2019.01.010
BibTex
@article{Zahiri2019Using-55309,
  year={2019},
  doi={10.1016/j.jgo.2019.01.010},
  title={Using wearables to screen motor performance deterioration because of cancer and chemotherapy-induced peripheral neuropathy (CIPN) in adults : Toward an early diagnosis of CIPN},
  number={6},
  volume={10},
  issn={1879-4068},
  journal={Journal of geriatric oncology},
  pages={960--967},
  author={Zahiri, Mohsen and Chen, Kevin M. and Zhou, He and Nguyen, Hung and Workeneh, Biruh T. and Yellapragada, Sarvari V. and Sada, Yvonne H. and Schwenk, Michael and Najafi, Bijan}
}
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