Direct monitoring of the conformational equilibria of the activation loop in the mitogen-activated protein kinase p38α

Roser, Patrick; Weisner, Jörn; Simard, Jeffrey R.; Rauh, Daniel; Drescher, Malte

Direct monitoring of the conformational equilibria of the activation loop in the mitogen-activated protein kinase p38α

Dateien

Zu diesem Dokument gibt es keine Dateien.

Datum

2018

Autor:innen

Roser, Patrick

Weisner, Jörn

Simard, Jeffrey R.

Rauh, Daniel

Drescher, Malte

DOI (zitierfähiger Link)

https://doi.org/10.1039/c8cc06128a

Sammlungen

Chemie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Chemical Communications : ChemComm. 2018, 54(85), pp. 12057-12060. ISSN 1359-7345. eISSN 1364-548X. Available under: doi: 10.1039/c8cc06128a

Zusammenfassung

Conformational transitions in protein kinases are crucial for the biological function of these enzymes. Here, we characterize and assess conformational equilibria of the activation loop and the effect of small molecule inhibitors in the MAP kinase p38α. Our work experimentally revealed the existence of a two-state equilibrium for p38α while the addition of inhibitors shifts the equilibrium between these two states.

Fachgebiet (DDC)

540 Chemie

Zitieren

ISO 690

ROSER, Patrick, Jörn WEISNER, Jeffrey R. SIMARD, Daniel RAUH, Malte DRESCHER, 2018. Direct monitoring of the conformational equilibria of the activation loop in the mitogen-activated protein kinase p38α. In: Chemical Communications : ChemComm. 2018, 54(85), pp. 12057-12060. ISSN 1359-7345. eISSN 1364-548X. Available under: doi: 10.1039/c8cc06128a

BibTex

@article{Roser2018-10-23Direc-43852,
  year={2018},
  doi={10.1039/c8cc06128a},
  title={Direct monitoring of the conformational equilibria of the activation loop in the mitogen-activated protein kinase p38α},
  number={85},
  volume={54},
  issn={1359-7345},
  journal={Chemical Communications : ChemComm},
  pages={12057--12060},
  author={Roser, Patrick and Weisner, Jörn and Simard, Jeffrey R. and Rauh, Daniel and Drescher, Malte}
}

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Universitätsbibliographie

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