A Chimeric GPCR Model Mimicking the Ligand Binding Site of the Human Y1 Receptor Studied by NMR Spectroscopy

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2011
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Walser, Reto
Zerbe, Oliver
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ChemBioChem. Wiley-VCH. 2011, 12(11), pp. 1690-1693. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.201100244
Zusammenfassung

Graft order: The putative binding epitopes of peptides of the NPY family at their cognate GPCR, the Y1 receptor, were grafted onto a stable β‐barrel scaffold. We demonstrate the synthetic feasibility of such an approach and discuss its potential benefits. The integrity of the scaffold as well as its interaction with NPY was studied by using solution NMR spectroscopy.

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570 Biowissenschaften, Biologie
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ISO 690WALSER, Reto, Jörg KLEINSCHMIDT, Oliver ZERBE, 2011. A Chimeric GPCR Model Mimicking the Ligand Binding Site of the Human Y1 Receptor Studied by NMR Spectroscopy. In: ChemBioChem. Wiley-VCH. 2011, 12(11), pp. 1690-1693. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.201100244
BibTex
@article{Walser2011-07-25Chime-51125,
  year={2011},
  doi={10.1002/cbic.201100244},
  title={A Chimeric GPCR Model Mimicking the Ligand Binding Site of the Human Y1 Receptor Studied by NMR Spectroscopy},
  number={11},
  volume={12},
  issn={1439-4227},
  journal={ChemBioChem},
  pages={1690--1693},
  author={Walser, Reto and Kleinschmidt, Jörg and Zerbe, Oliver}
}
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