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Effects of serotonergic psychedelics on mitochondria : Transdiagnostic implications for mitochondria-related pathologies

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2023

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Fissler, Patrick
Vandersmissen, Anja
Mavioglu, Rezan Nehir
Scholkmann, Felix
Karabatsiakis, Alexander
Krähenmann, Rainer

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Journal of Psychopharmacology. Sage. 2023, 37(7), pp. 679-686. ISSN 0269-8811. eISSN 1461-7285. Available under: doi: 10.1177/02698811231164707

Zusammenfassung

The use of serotonergic psychedelics has gained increasing attention in research, clinical practice and society. Growing evidence suggests fast-acting, transdiagnostic health benefits of these 5-hydroxytryptamine 2A receptor agonists. Here, we provide a brief overview of their benefits for psychological, cardiovascular, metabolic, neurodegenerative, and immunological pathologies. We then review their effect on mitochondria including mitochondrial biogenesis, functioning and transport. Mitochondrial dysregulation is a transdiagnostic mechanism that contributes to the aforementioned pathologies. Hence, we postulate that psychedelic-induced effects on mitochondria partially underlie their transdiagnostic benefits. Based on this assumption, we propose new treatment indications for psychedelics and that the health benefits induced by psychedelics depend on patient-specific mitochondrial dysregulation.

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150 Psychologie

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ISO 690FISSLER, Patrick, Anja VANDERSMISSEN, Marco FILIPPI, Rezan Nehir MAVIOGLU, Felix SCHOLKMANN, Alexander KARABATSIAKIS, Rainer KRÄHENMANN, 2023. Effects of serotonergic psychedelics on mitochondria : Transdiagnostic implications for mitochondria-related pathologies. In: Journal of Psychopharmacology. Sage. 2023, 37(7), pp. 679-686. ISSN 0269-8811. eISSN 1461-7285. Available under: doi: 10.1177/02698811231164707
BibTex
@article{Fissler2023-04-25Effec-68205,
  year={2023},
  doi={10.1177/02698811231164707},
  title={Effects of serotonergic psychedelics on mitochondria : Transdiagnostic implications for mitochondria-related pathologies},
  number={7},
  volume={37},
  issn={0269-8811},
  journal={Journal of Psychopharmacology},
  pages={679--686},
  author={Fissler, Patrick and Vandersmissen, Anja and Filippi, Marco and Mavioglu, Rezan Nehir and Scholkmann, Felix and Karabatsiakis, Alexander and Krähenmann, Rainer}
}
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