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Neural mechanisms of a genome-wide supported psychosis variant

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2009

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Esslinger, Christine
Walter, Henrik
Kirsch, Peter
Erk, Susanne
Schnell, Knut
Arnold, Claudia
Haddad, Leila
Opitz von Boberfeld, Carola
Meyer-Lindenberg, Andreas
et al.

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https://doi.org/10.1126/science.1167768
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Science. 2009, 324(5927), pp. 605. ISSN 0036-8075. eISSN 1095-9203. Available under: doi: 10.1126/science.1167768

Zusammenfassung

Schizophrenia is a devastating, highly heritable brain disorder of unknown etiology. Recently, the first common genetic variant associated on a genome-wide level with schizophrenia and possibly bipolar disorder was discovered in ZNF804A (rs1344706). We show, by using an imaging genetics approach, that healthy carriers of rs1344706 risk genotypes exhibit no changes in regional activity but pronounced gene dosage-dependent alterations in functional coupling (correlated activity) of dorsolateral prefrontal cortex (DLPFC) across hemispheres and with hippocampus, mirroring findings in patients, and abnormal coupling of amygdala. Our findings establish disturbed connectivity as a neurogenetic risk mechanism for psychosis supported by genome-wide association, show that rs1344706 or variation in linkage disequilibrium is functional in human brain, and validate the intermediate phenotype strategy in psychiatry.

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150 Psychologie

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ISO 690ESSLINGER, Christine, Henrik WALTER, Peter KIRSCH, Susanne ERK, Knut SCHNELL, Claudia ARNOLD, Leila HADDAD, Daniela MIER, Carola OPITZ VON BOBERFELD, Andreas MEYER-LINDENBERG, 2009. Neural mechanisms of a genome-wide supported psychosis variant. In: Science. 2009, 324(5927), pp. 605. ISSN 0036-8075. eISSN 1095-9203. Available under: doi: 10.1126/science.1167768
BibTex
@article{Esslinger2009-05-01Neura-45882,
  year={2009},
  doi={10.1126/science.1167768},
  title={Neural mechanisms of a genome-wide supported psychosis variant},
  number={5927},
  volume={324},
  issn={0036-8075},
  journal={Science},
  author={Esslinger, Christine and Walter, Henrik and Kirsch, Peter and Erk, Susanne and Schnell, Knut and Arnold, Claudia and Haddad, Leila and Mier, Daniela and Opitz von Boberfeld, Carola and Meyer-Lindenberg, Andreas}
}
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