Publikation: Synthesis of disaccharide nucleoside analogues as potential poly(ADP-ribose) polymerase-1 inhibitors
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Organic & Biomolecular Chemistry. 2018, 16(46), pp. 8904-8907. ISSN 1477-0520. eISSN 1477-0539. Available under: doi: 10.1039/c8ob01894d
Zusammenfassung
Poly(ADP-ribose) polymerase-1 (PARP-1) is an important target in cancer therapy. We present the synthesis of novel disaccharide nucleoside analogues that resemble the central motif of poly(ADP-ribose) and test their inhibitory effects on human PARP-1. Some compounds show inhibition of enzymatic activity in vitro and thus might be interesting for further investigations.
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ZHENG, Meng, Martin MEX, Kathrin H. GÖTZ, Andreas MARX, 2018. Synthesis of disaccharide nucleoside analogues as potential poly(ADP-ribose) polymerase-1 inhibitors. In: Organic & Biomolecular Chemistry. 2018, 16(46), pp. 8904-8907. ISSN 1477-0520. eISSN 1477-0539. Available under: doi: 10.1039/c8ob01894dBibTex
@article{Zheng2018-11-28Synth-44414,
year={2018},
doi={10.1039/c8ob01894d},
title={Synthesis of disaccharide nucleoside analogues as potential poly(ADP-ribose) polymerase-1 inhibitors},
number={46},
volume={16},
issn={1477-0520},
journal={Organic & Biomolecular Chemistry},
pages={8904--8907},
author={Zheng, Meng and Mex, Martin and Götz, Kathrin H. and Marx, Andreas}
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