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Genomic structure, conservation and FISH mapping of the Rattus norvegicus Adprt gene

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2002

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Kappler, Roland
Scherthan, Harry

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https://doi.org/10.1159/000071052
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Cytogenetic and Genome Research. Karger. 2002, 98(4), pp. 298-301. ISSN 1424-8581. eISSN 1424-859X. Available under: doi: 10.1159/000071052

Zusammenfassung

Poly(ADP-ribose) polymerase 1 (PARP-1) lies at the basis of a DNA-interacting protein family that maintains genome integrity. Here we describe the genomic organisation of rat PARP-1 gene (Adprt), refine its assignment to rat chromosome (RNO) 13q25-->q26 by FISH and compare its genomic organisation between rat, mouse and human. It appears that in human, mouse and rat Adprt consists of 23 similar-sized exons with well-conserved intron and exon borders. Adprt orthologs map to homologous chromosome regions at the termini of the q-arms of human and mouse chromosomes 1 and rat 13, with gene order being conserved between the rodents. Kimura protein distance comparison with human PARP-1 as reference revealed the bovine protein to be the least conserved with 10.3 substitutions per 100 amino acids, followed by rat (8.6) and mouse (8.4).

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570 Biowissenschaften, Biologie

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ISO 690BENEKE, Sascha, Roland KAPPLER, Alexander BÜRKLE, Harry SCHERTHAN, 2002. Genomic structure, conservation and FISH mapping of the Rattus norvegicus Adprt gene. In: Cytogenetic and Genome Research. Karger. 2002, 98(4), pp. 298-301. ISSN 1424-8581. eISSN 1424-859X. Available under: doi: 10.1159/000071052
BibTex
@article{Beneke2002Genom-53154,
  year={2002},
  doi={10.1159/000071052},
  title={Genomic structure, conservation and FISH mapping of the Rattus norvegicus Adprt gene},
  number={4},
  volume={98},
  issn={1424-8581},
  journal={Cytogenetic and Genome Research},
  pages={298--301},
  author={Beneke, Sascha and Kappler, Roland and Bürkle, Alexander and Scherthan, Harry}
}
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