Publikation:

The AMSH3 ESCRT-III-Associated Deubiquitinase Is Essential for Plant Immunity

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Datum

2018

Autor:innen

Schultz-Larsen, Torsten
Lenk, Andrea
Kalinowska, Kamila
Vestergaard, Lau Kræsing
Pedersen, Carsten
Thordal-Christensen, Hans

Herausgeber:innen

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URI (zitierfähiger Link)
http://nbn-resolving.de/urn:nbn:de:bsz:352-2-1rc1n0gy5n04i0
DOI (zitierfähiger Link)
https://doi.org/10.1016/j.celrep.2018.11.011
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Internationale Patentnummer

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CC BY-NC-ND 4.0

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Open Access-Veröffentlichung
Open Access Gold

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Biologie: Publikationen
Core Facility der Universität Konstanz

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Titel in einer weiteren Sprache

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Published

Erschienen in

Cell Reports. 2018, 25(9), pp. 2329-2338. eISSN 2211-1247. Available under: doi: 10.1016/j.celrep.2018.11.011

Zusammenfassung

Plant "nucleotide-binding leucine-rich repeat" receptor proteins (NLRs) detect alterations in host targets of pathogen effectors and trigger immune responses. The Arabidopsis thaliana mutant pen1 syp122 displays autoimmunity, and a mutant screen identified the deubiquitinase "associated molecule with the SH3 domain of STAM3" (AMSH3) to be required for this phenotype. AMSH3 has previously been implicated in ESCRT-mediated vacuolar targeting. Pathology experiments show that AMSH3 activity is required for immunity mediated by the CC-NLRs, RPS2 and RPM1. Co-expressing the autoactive RPM1D505V and the catalytically inactive ESCRT-III protein SKD1E232Q in Nicotiana benthamiana supports the requirement of ESCRT-associated functions for this CC-NLR-activated immunity. Meanwhile, loss of ESCRT function in A. thaliana is lethal, and we find that AMSH3 knockout-triggered seedling lethality is "enhanced disease susceptibility 1" (EDS1) dependent. Future studies may reveal whether AMSH3 is monitored by a TIR-NLR immunity receptor.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

plant immunity autoimmunity, AMSH3 deubiquitinase, ESCRT, nucleotide-binding leucine-rich repeat receptors

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ISO 690SCHULTZ-LARSEN, Torsten, Andrea LENK, Kamila KALINOWSKA, Lau Kræsing VESTERGAARD, Carsten PEDERSEN, Erika ISONO, Hans THORDAL-CHRISTENSEN, 2018. The AMSH3 ESCRT-III-Associated Deubiquitinase Is Essential for Plant Immunity. In: Cell Reports. 2018, 25(9), pp. 2329-2338. eISSN 2211-1247. Available under: doi: 10.1016/j.celrep.2018.11.011
BibTex
@article{SchultzLarsen2018-11-27AMSH3-45320,
  year={2018},
  doi={10.1016/j.celrep.2018.11.011},
  title={The AMSH3 ESCRT-III-Associated Deubiquitinase Is Essential for Plant Immunity},
  number={9},
  volume={25},
  journal={Cell Reports},
  pages={2329--2338},
  author={Schultz-Larsen, Torsten and Lenk, Andrea and Kalinowska, Kamila and Vestergaard, Lau Kræsing and Pedersen, Carsten and Isono, Erika and Thordal-Christensen, Hans}
}
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