Publikation: A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor beta chain and a 33 kd glycoprotein.
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We describe a novel signal-transducing protein complex, which consists of the T cell receptor (TCR) β chain that is disulfide linked to a 33 kd glycoprotein and non-covalently associated with proteins of the CD3 complex on the surface of the pre-T cell line SCB.29. This 33 kd glycoprotein, provisionally designated gp33, represents neither of the known TCR chains and has escaped previous detection because it labels poorly by surface iodination. This glycoprotein is absent from the surface of mature T cell lines. A TCR β complex with identical molecular masses before and after reduction can be immunoprecipitated from surface-iodinated large thymocytes of TCR α-deficient mice. The novel gp33-TCR β complex may be entirely or partly responsible for control of early T cell development exerted by the TCR β protein.
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GRÖTTRUP, Marcus, Katharina UNGEWISS, Orly AZOGUI, Ronald PALACIOS, Michael J. OWEN, Adrian C. HAYDAY, Harald von BOEHMER, 1993. A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor beta chain and a 33 kd glycoprotein.. In: Cell. 1993, 75(2), pp. 283-294. ISSN 0092-8674. Available under: doi: 10.1016/0092-8674(93)80070-UBibTex
@article{Grottrup1993novel-16676, year={1993}, doi={10.1016/0092-8674(93)80070-U}, title={A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor beta chain and a 33 kd glycoprotein.}, number={2}, volume={75}, issn={0092-8674}, journal={Cell}, pages={283--294}, author={Gröttrup, Marcus and Ungewiss, Katharina and Azogui, Orly and Palacios, Ronald and Owen, Michael J. and Hayday, Adrian C. and Boehmer, Harald von} }
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