Magnetic resonance volumetry and spectroscopy of hippocampus and insula in relation to severe exposure of traumatic stress

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2012
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Kaufmann, Jörn
Kanowski, Martin
Tempelmann, Claus
Hinrichs, Hermann
Heinze, Hans-Jochen
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Severe and chronic stress affects the hippocampus, especially during development. However, studies concerning structural alterations of the hippocampus yielded a rather inconsistent picture. Moreover, further anxiety-relevant brain regions, such as the insula, might be implicated in the pathophysiology of posttraumatic stress disorder (PTSD). We combined magnetic resonance (MR) volumetric and spectroscopic analyses of hippocampus and insula in highly traumatized refugees without a history of alcohol/substance abuse or other comorbid diseases. No PTSD-related difference was apparent in the volumes or neurometabolite levels of bilateral hippocampus or insula. However, an association between left hippocampal N-acetyl-aspartate (NAA) and adverse childhood experiences indicated a potential detrimental effect of the early environment on hippocampal integrity. Our results add to increasing evidence that PTSD-related, morphological alterations in the hippocampus are a consequence of early adversity or may result from other factors, such as extensive use of alcohol.

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ISO 690ECKART, Cindy, Jörn KAUFMANN, Martin KANOWSKI, Claus TEMPELMANN, Hermann HINRICHS, Thomas ELBERT, Hans-Jochen HEINZE, Iris-Tatjana KOLASSA, 2012. Magnetic resonance volumetry and spectroscopy of hippocampus and insula in relation to severe exposure of traumatic stress. In: Psychophysiology. 2012, 49(2), pp. 261-270. ISSN 0048-5772. eISSN 1540-5958. Available under: doi: 10.1111/j.1469-8986.2011.01303.x
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@article{Eckart2012-02Magne-21898,
  year={2012},
  doi={10.1111/j.1469-8986.2011.01303.x},
  title={Magnetic resonance volumetry and spectroscopy of hippocampus and insula in relation to severe exposure of traumatic stress},
  number={2},
  volume={49},
  issn={0048-5772},
  journal={Psychophysiology},
  pages={261--270},
  author={Eckart, Cindy and Kaufmann, Jörn and Kanowski, Martin and Tempelmann, Claus and Hinrichs, Hermann and Elbert, Thomas and Heinze, Hans-Jochen and Kolassa, Iris-Tatjana}
}
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