Publikation:

Truxillic acid derivatives act as peroxisome proliferator-activated receptor γ activators

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2010

Autor:innen

Steri, Ramona
Proschak, Ewgenij
Schroeter, Timon
Zettl, Heiko
Hansen, Katja
Schwarz, Oliver
Müller-Kuhrt, Lutz
Müller, Klaus-Robert
Schubert-Zsilavecz, Manfred
et al.

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https://doi.org/10.1016/j.bmcl.2010.03.026
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Bioorganic & Medicinal Chemistry Letters. Elsevier. 2010, 20(9), pp. 2920-2923. ISSN 0960-894X. eISSN 1464-3405. Available under: doi: 10.1016/j.bmcl.2010.03.026

Zusammenfassung

In previous studies, we identified a truxillic acid derivative as selective activator of the peroxisome proliferator-activated receptor gamma, which is a member of the nuclear receptor family and acts as ligand-activated transcription factor of genes involved in glucose metabolism. Herein we present the structure-activity relationships of 16 truxillic acid derivatives, investigated by a cell-based reporter gene assay guided by molecular docking analysis.

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004 Informatik

Schlagwörter

Nuclear receptors, PPARγ, Truxillic acid derivatives, Reporter gene assay, Molecular docking, Structure–activity relationships

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ISO 690STERI, Ramona, Matthias RUPP, Ewgenij PROSCHAK, Timon SCHROETER, Heiko ZETTL, Katja HANSEN, Oliver SCHWARZ, Lutz MÜLLER-KUHRT, Klaus-Robert MÜLLER, Manfred SCHUBERT-ZSILAVECZ, 2010. Truxillic acid derivatives act as peroxisome proliferator-activated receptor γ activators. In: Bioorganic & Medicinal Chemistry Letters. Elsevier. 2010, 20(9), pp. 2920-2923. ISSN 0960-894X. eISSN 1464-3405. Available under: doi: 10.1016/j.bmcl.2010.03.026
BibTex
@article{Steri2010-05-01Truxi-53264,
  year={2010},
  doi={10.1016/j.bmcl.2010.03.026},
  title={Truxillic acid derivatives act as peroxisome proliferator-activated receptor γ activators},
  number={9},
  volume={20},
  issn={0960-894X},
  journal={Bioorganic & Medicinal Chemistry Letters},
  pages={2920--2923},
  author={Steri, Ramona and Rupp, Matthias and Proschak, Ewgenij and Schroeter, Timon and Zettl, Heiko and Hansen, Katja and Schwarz, Oliver and Müller-Kuhrt, Lutz and Müller, Klaus-Robert and Schubert-Zsilavecz, Manfred}
}
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