Publikation:

Clinical significance of cell cycle- and apoptosis-related markers in biliary tract cancer : a tissue microarray-based approach revealing a distinctive immunophenotype for intrahepatic and extrahepatic cholangiocarcinomas

Vorschaubild

Dateien

2008_Karamitopoulou_AJCP_08.pdf
2008_Karamitopoulou_AJCP_08.pdfGröße: 702.77 KBDownloads: 416

Datum

2008

Autor:innen

Karamitopoulou, Eva
Tornillo, Luigi
Zlobec, Inti
Cioccari, Lukas
Carafa, Vincenza
Borner, Markus
Schaffner, Thomas
Diamantis, Ioannis
Zimmermann, Arthur
1 mehr anzeigen

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

URI (zitierfähiger Link)
http://nbn-resolving.de/urn:nbn:de:bsz:352-142636
DOI (zitierfähiger Link)
https://doi.org/10.1309/AJCP35FDCAVANWMM
ArXiv-ID

Internationale Patentnummer

Link zur Lizenz
Urheberrechtlich geschützt

Angaben zur Forschungsförderung

Projekt

Open Access-Veröffentlichung
Open Access Green

Sammlungen

Biologie: Publikationen
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

American Journal of Clinical Pathology. 2008, 130(5), pp. 780-786. ISSN 0002-9173. eISSN 1943-7722. Available under: doi: 10.1309/AJCP35FDCAVANWMM

Zusammenfassung

Cholangiocarcinoma is the second most common malignant tumor of the liver. We analyzed, immunohistochemically, the significance of cell cycle– and apoptosis-related markers in 128 cholangiocarcinomas (42 intrahepatic, 70 extrahepatic, and 16 gallbladder carcinomas) combined in a tissue microarray. Follow-up was available for 57 patients (44.5%). In comparison with normal tissue (29 specimens), cholangiocarcinomas expressed significantly more frequently p53, bcl-2, bax, and COX-2 (P < .05). Intrahepatic tumors were significantly more frequently bcl-2+ and p16+, whereas extrahepatic tumors were more often p53+ (P < .05). Loss of p16 expression was associated with reduced survival of patients. Our data show that p53, bcl-2, bax, and COX-2 have an important role in the pathogenesis of cholangiocarcinomas. The differential expression of p16, bcl-2, and p53 between intrahepatic and extrahepatic tumors demonstrates that there are location-related differences in the phenotype and the genetic profiles of these tumors. Moreover, p16 was identified as an important prognostic marker in cholangiocarcinomas.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Cholangiocarcinoma, Prognosis, Tissue microarray

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Zugehörige Datensätze in KOPS

Zitieren

ISO 690KARAMITOPOULOU, Eva, Luigi TORNILLO, Inti ZLOBEC, Lukas CIOCCARI, Vincenza CARAFA, Markus BORNER, Thomas SCHAFFNER, Thomas BRUNNER, Ioannis DIAMANTIS, Arthur ZIMMERMANN, Luigi TERRACCIANO, 2008. Clinical significance of cell cycle- and apoptosis-related markers in biliary tract cancer : a tissue microarray-based approach revealing a distinctive immunophenotype for intrahepatic and extrahepatic cholangiocarcinomas. In: American Journal of Clinical Pathology. 2008, 130(5), pp. 780-786. ISSN 0002-9173. eISSN 1943-7722. Available under: doi: 10.1309/AJCP35FDCAVANWMM
BibTex
@article{Karamitopoulou2008-11Clini-14263,
  year={2008},
  doi={10.1309/AJCP35FDCAVANWMM},
  title={Clinical significance of cell cycle- and apoptosis-related markers in biliary tract cancer : a tissue microarray-based approach revealing a distinctive immunophenotype for intrahepatic and extrahepatic cholangiocarcinomas},
  number={5},
  volume={130},
  issn={0002-9173},
  journal={American Journal of Clinical Pathology},
  pages={780--786},
  author={Karamitopoulou, Eva and Tornillo, Luigi and Zlobec, Inti and Cioccari, Lukas and Carafa, Vincenza and Borner, Markus and Schaffner, Thomas and Brunner, Thomas and Diamantis, Ioannis and Zimmermann, Arthur and Terracciano, Luigi}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/14263">
    <dc:creator>Karamitopoulou, Eva</dc:creator>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/14263"/>
    <dc:creator>Borner, Markus</dc:creator>
    <dc:creator>Zimmermann, Arthur</dc:creator>
    <dc:contributor>Schaffner, Thomas</dc:contributor>
    <dc:contributor>Carafa, Vincenza</dc:contributor>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:language>eng</dc:language>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/14263/2/2008_Karamitopoulou_AJCP_08.pdf"/>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-10-19T08:59:39Z</dcterms:available>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:creator>Diamantis, Ioannis</dc:creator>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:creator>Zlobec, Inti</dc:creator>
    <dc:contributor>Terracciano, Luigi</dc:contributor>
    <dc:creator>Cioccari, Lukas</dc:creator>
    <dc:contributor>Zlobec, Inti</dc:contributor>
    <dc:creator>Schaffner, Thomas</dc:creator>
    <dc:creator>Tornillo, Luigi</dc:creator>
    <dc:contributor>Diamantis, Ioannis</dc:contributor>
    <dc:creator>Carafa, Vincenza</dc:creator>
    <dc:contributor>Zimmermann, Arthur</dc:contributor>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dcterms:bibliographicCitation>First publ. in: American Journal of Clinical Pathology ; 130 (2008), 5. - pp. 780-786</dcterms:bibliographicCitation>
    <dc:contributor>Borner, Markus</dc:contributor>
    <dc:rights>terms-of-use</dc:rights>
    <dc:contributor>Karamitopoulou, Eva</dc:contributor>
    <dc:creator>Brunner, Thomas</dc:creator>
    <dc:contributor>Cioccari, Lukas</dc:contributor>
    <dc:contributor>Tornillo, Luigi</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-10-19T08:59:39Z</dc:date>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dcterms:abstract xml:lang="eng">Cholangiocarcinoma is the second most common malignant tumor of the liver. We analyzed, immunohistochemically, the significance of cell cycle– and apoptosis-related markers in 128 cholangiocarcinomas (42 intrahepatic, 70 extrahepatic, and 16 gallbladder carcinomas) combined in a tissue microarray. Follow-up was available for 57 patients (44.5%). In comparison with normal tissue (29 specimens), cholangiocarcinomas expressed significantly more frequently p53, bcl-2, bax, and COX-2 (P &lt; .05). Intrahepatic tumors were significantly more frequently bcl-2+ and p16+, whereas extrahepatic tumors were more often p53+ (P &lt; .05). Loss of p16 expression was associated with reduced survival of patients. Our data show that p53, bcl-2, bax, and COX-2 have an important role in the pathogenesis of cholangiocarcinomas. The differential expression of p16, bcl-2, and p53 between intrahepatic and extrahepatic tumors demonstrates that there are location-related differences in the phenotype and the genetic profiles of these tumors. Moreover, p16 was identified as an important prognostic marker in cholangiocarcinomas.</dcterms:abstract>
    <dc:contributor>Brunner, Thomas</dc:contributor>
    <dc:creator>Terracciano, Luigi</dc:creator>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/14263/2/2008_Karamitopoulou_AJCP_08.pdf"/>
    <dcterms:title>Clinical significance of cell cycle- and apoptosis-related markers in biliary tract cancer : a tissue microarray-based approach revealing a distinctive immunophenotype for intrahepatic and extrahepatic cholangiocarcinomas</dcterms:title>
    <dcterms:issued>2008-11</dcterms:issued>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Nein
Begutachtet
Diese Publikation teilen