Verbal working memory‐related neural network communication in schizophrenia

Abstract

Impaired working memory (WM) in schizophrenia is associated with reduced hemodynamic and electromagnetic activity and altered network connectivity within and between memory‐associated neural networks. The present study sought to determine whether schizophrenia involves disruption of a frontal‐parietal network normally supporting WM and/or involvement of another brain network. Nineteen schizophrenia patients (SZ) and 19 healthy comparison subjects (HC) participated in a cued visual‐verbal Sternberg task while dense‐array EEG was recorded. A pair of item arrays each consisting of 2–4 consonants was presented bilaterally for 200 ms with a prior cue signaling the hemifield of the task‐relevant WM set. A central probe letter 2,000 ms later prompted a choice reaction time decision about match/mismatch with the target WM set. Group and WM load effects on time domain and time‐frequency domain 11–15 Hz alpha power were assessed for the cue‐to‐probe time window, and posterior 11–15 Hz alpha power and frontal 4–8 Hz theta power were assessed during the retention period. Directional connectivity was estimated via Granger causality, evaluating group differences in communication. SZ showed slower responding, lower accuracy, smaller overall time‐domain alpha power increase, and less load‐dependent alpha power increase. Midline frontal theta power increases did not vary by group or load. Network communication in SZ was characterized by temporal‐to‐posterior information flow, in contrast to bidirectional temporal‐posterior communication in HC. Results indicate aberrant WM network activity supporting WM in SZ that might facilitate normal load‐dependent and only marginally less accurate task performance, despite generally slower responding.