@article{Gerhardt2001-04Casca-51267,
  year={2001},
  doi={10.1006/mcne.2001.0962},
  title={Cascade of Caspase Activation in Potassium-Deprived Cerebellar Granule Neurons : Targets for Treatment with Peptide and Protein Inhibitors of Apoptosis},
  number={4},
  volume={17},
  issn={1044-7431},
  journal={Molecular and Cellular Neuroscience},
  pages={717--731},
  author={Gerhardt, Ellen and Kügler, Sebastian and Leist, Marcel and Beier, Christoph and Berliocchi, Laura and Volbracht, Christiane and Weller, Michael and Bähr, Mathias and Nicotera, Pierluigi and Schulz, Jörg B.}
}

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    <dc:creator>Nicotera, Pierluigi</dc:creator>
    <dcterms:abstract xml:lang="eng">Cerebellar granule neurons (CGN) cultured in the presence of serum and depolarizing potassium concentrations undergo apoptosis when switched to serum-free medium containing physiological potassium concentrations. Here we show that processing of the key protease, caspase-3, depends on the activation of caspase-9, but not of caspase-8. Selective peptide inhibitors of caspase-9 block processing of caspase-3 and caspase-8 and inhibit apoptosis, whereas a selective inhibitor of caspase-8 blocks neither processing of caspase-3 nor cell death. The data obtained with peptide inhibitors were confirmed by adenovirally mediated ectopic expression of the cytokine response modifier A (crmA), the baculovirus protein p35, and the X chromosome-linked inhibitor of apoptosis (XIAP). Further, caspase-8-activating death receptors do not mediate apoptosis in CGN and potassium withdrawal-induced apoptosis evolves unaltered in gld or lpr mice, which harbor mutations in the CD95/CD95 ligand system. Thus, neuronal apoptosis triggered by potassium deprivation is death receptor-independent but involves the mitochondrial pathway of caspase activation.</dcterms:abstract>
    <dc:creator>Volbracht, Christiane</dc:creator>
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    <dc:contributor>Gerhardt, Ellen</dc:contributor>
    <dc:creator>Schulz, Jörg B.</dc:creator>
    <dcterms:issued>2001-04</dcterms:issued>
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    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2020-10-09T06:58:41Z</dc:date>
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    <dc:creator>Weller, Michael</dc:creator>
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    <dc:creator>Leist, Marcel</dc:creator>
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    <dc:creator>Bähr, Mathias</dc:creator>
    <dc:contributor>Schulz, Jörg B.</dc:contributor>
    <dcterms:title>Cascade of Caspase Activation in Potassium-Deprived Cerebellar Granule Neurons : Targets for Treatment with Peptide and Protein Inhibitors of Apoptosis</dcterms:title>
    <dc:contributor>Volbracht, Christiane</dc:contributor>
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    <dc:contributor>Beier, Christoph</dc:contributor>
    <dc:creator>Beier, Christoph</dc:creator>
    <dc:contributor>Leist, Marcel</dc:contributor>
    <dc:language>eng</dc:language>
    <dc:contributor>Berliocchi, Laura</dc:contributor>
    <dc:creator>Berliocchi, Laura</dc:creator>
    <dc:contributor>Bähr, Mathias</dc:contributor>
    <dc:contributor>Kügler, Sebastian</dc:contributor>
    <dc:creator>Kügler, Sebastian</dc:creator>
    <dc:contributor>Weller, Michael</dc:contributor>
    <dc:creator>Gerhardt, Ellen</dc:creator>
    <dc:contributor>Nicotera, Pierluigi</dc:contributor>
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