Publikation:

Switching between individual and collective motility in B lymphocytes is controlled by cell-matrix adhesion and inter-cellular interactions

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Datum

2018

Autor:innen

Rey-Barroso, Javier
Calovi, Daniel S.
Combe, Maud
German, Yolla
Moreau, Mathieu
Canivet, Astrid
Wang, Xiaobo
Sire, Clément
Theraulaz, Guy
Dupré, Loïc

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http://nbn-resolving.de/urn:nbn:de:bsz:352-2-1phf3mxy8md225
DOI (zitierfähiger Link)
https://doi.org/10.1038/s41598-018-24222-4
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CC BY 4.0

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Open Access-Veröffentlichung
Open Access Gold

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Biologie: Publikationen
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Published

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Scientific reports. Springer Nature. 2018, 8(1), 5800. eISSN 2045-2322. Available under: doi: 10.1038/s41598-018-24222-4

Zusammenfassung

Lymphocytes alternate between phases of individual migration across tissues and phases of clustering during activation and function. The range of lymphocyte motility behaviors and the identity of the factors that govern them remain elusive. To explore this point, we here collected unprecedented statistics pertaining to cell displacements, cell:matrix and cell:cell interactions using a model B cell line as well as primary human B lymphocytes. At low cell density, individual B lymphocytes displayed a high heterogeneity in their speed and diffusivity. Beyond this intrinsic variability, B lymphocytes adapted their motility to the composition of extra-cellular matrix, adopting slow persistent walks over collagen IV and quick Brownian walks over fibronectin. At high cell density, collagen IV favored the self-assembly of B lymphocytes into clusters endowed with collective coordination, while fibronectin stimulated individual motility. We show that this behavioral plasticity is controlled by acto-myosin dependent adhesive and Arp2/3-dependent protrusive actin pools, respectively. Our study reveals the adaptive nature of B lymphocyte motility and group dynamics, which are shaped by an interplay between and cell:matrix and cell:cell interactions.

Zusammenfassung in einer weiteren Sprache

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570 Biowissenschaften, Biologie

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ISO 690REY-BARROSO, Javier, Daniel S. CALOVI, Maud COMBE, Yolla GERMAN, Mathieu MOREAU, Astrid CANIVET, Xiaobo WANG, Clément SIRE, Guy THERAULAZ, Loïc DUPRÉ, 2018. Switching between individual and collective motility in B lymphocytes is controlled by cell-matrix adhesion and inter-cellular interactions. In: Scientific reports. Springer Nature. 2018, 8(1), 5800. eISSN 2045-2322. Available under: doi: 10.1038/s41598-018-24222-4
BibTex
@article{ReyBarroso2018Switc-53400,
  year={2018},
  doi={10.1038/s41598-018-24222-4},
  title={Switching between individual and collective motility in B lymphocytes is controlled by cell-matrix adhesion and inter-cellular interactions},
  number={1},
  volume={8},
  journal={Scientific reports},
  author={Rey-Barroso, Javier and Calovi, Daniel S. and Combe, Maud and German, Yolla and Moreau, Mathieu and Canivet, Astrid and Wang, Xiaobo and Sire, Clément and Theraulaz, Guy and Dupré, Loïc},
  note={Article Number: 5800}
}
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