Publikation:

High-resolution phenotypic profiling of natural products-induced effects on the single-cell level

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Kremb_2-1p2jrjd4q2kpd3.pdf
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Datum

2017

Autor:innen

Kremb, Stephan

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http://nbn-resolving.de/urn:nbn:de:bsz:352-2-1p2jrjd4q2kpd3
DOI (zitierfähiger Link)
https://doi.org/10.1038/srep44472
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CC BY 4.0

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Open Access-Veröffentlichung
Open Access Gold

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Biologie: Publikationen
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Published

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Scientific Reports. Springer Nature. 2017, 7, 44472. eISSN 2045-2322. Available under: doi: 10.1038/srep44472

Zusammenfassung

Natural products (NPs) are highly evolved molecules making them a valuable resource for new therapeutics. Here we demonstrate the usefulness of broad-spectrum phenotypic profiling of NP-induced perturbations on single cells with imaging-based High-Content Screening to inform on physiology, mechanisms-of-actions, and multi-level toxicity. Our technology platform aims at broad applicability using a comprehensive marker panel with standardized settings streamlined towards an easy implementation in laboratories dedicated to natural products research.

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Fachgebiet (DDC)
570 Biowissenschaften, Biologie

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ISO 690KREMB, Stephan, Christian R. VOOLSTRA, 2017. High-resolution phenotypic profiling of natural products-induced effects on the single-cell level. In: Scientific Reports. Springer Nature. 2017, 7, 44472. eISSN 2045-2322. Available under: doi: 10.1038/srep44472
BibTex
@article{Kremb2017Highr-50744,
  year={2017},
  doi={10.1038/srep44472},
  title={High-resolution phenotypic profiling of natural products-induced effects on the single-cell level},
  volume={7},
  journal={Scientific Reports},
  author={Kremb, Stephan and Voolstra, Christian R.},
  note={Article Number: 44472}
}
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